Table 4.
Initial imaging and CSF analysis of MS patients
| Investigations | Total (n=186) | EOPMS (<12 years) (n=47) | LOPMS (>12 years) (n=139) | P-value |
|---|---|---|---|---|
| Brain MRI | ||||
| Typical lesions | 132 (70.97%) | 23 (48.94%) | 109 (78.42%) | 0.036 |
| Atypical lesions | 54 (29.03%) | 24 (51.06%) | 30 (21.58%) | 0.028 |
| Confluent lesions | 22 (11.83%) | 16 (34.04%) | 6 (4.32%) | 0.001 |
| Few non-specific white matter hyperintensities | 32 (17.20%) | 8 (17.02%) | 24 (17.27%) | 0.81 |
| Gd+ | 66 (35.48%) | 12 (25.53%) | 54 (38.85%) | 0.09 |
| Black holes | 26 (13.98%) | 9 (19.15%) | 17 (12.23%) | 0.78 |
| Infra-tentorial lesions | 64 (34.41%) | 27 (57.45%) | 37 (26.62%) | 0.03 |
| Cervical MRI | ||||
| Not done | 25 (13.44%) | 7 (14.89%) | 18 (12.95%) | 0.71 |
| Normal | 34 (18.28%) | 9 (19.15%) | 25 (17.99%) | 0.69 |
| Positive | 127 (68.28%) | 31 (65.96%) | 96 (69.06%) | 0.87 |
| CSF analysis (n=34) | ||||
| Elevated CSF IgG index | 29/34 (85.29%) | 15/18 (83.33%) | 14/16 (87.50%) | 0.62 |
| Positive OCB | 27/34 (79.41%) | 14/18 (77.78%) | 13/16 (81.25%) | 0.67 |
Abbreviations: CSF, cerebrospinal fluid; EOPMS, early onset pediatric multiple sclerosis; Gd, gadolinium; LOPMS, late onset pediatric multiple sclerosis; MRI, magnetic resonance imaging; MS, multiple sclerosis; OCB, oligoclonal bands.