Table 2.
Differences in abundances of taxa in APS-1 and control saliva. Significant (p ≤ 0.05) differences in relative abundance of taxa from control saliva and APS-1 saliva as estimated by Metastats http://cbcb.umd.edu/software/metastats. Differences significant after Bonferonni Correction for multiple testing are marked with *.
| Taxon | APS-1 saliva (n = 7) | Control saliva (n = 17) | Metastat p-value |
|---|---|---|---|
| Phyla | |||
| Firmicutes | 0.65118 ± 0.02551 | 0.41118 ± 0.02572 | 0.002 |
| Bacteroidetes | 0.11271 ± 0.03162 | 0.26009 ± 0.03845 | 0.007 |
| Genera | |||
| Streptococcus | 0.53448 ± 0.08523 | 0.18016 ± 0.01963 | 0.0001* |
| Gemella | 0.01467 ± 0.00023 | 0.00253 ± 0.00062 | 0.036 |
| Prevotella | 0.05995 ± 0.01021 | 0.17357 ± 0.02970 | 0.001 |
| Veillonella | 0.04049 ± 0.00925 | 0.16254 ± 0.02760 | 0.0001* |
| Neissera | 0.02065 ± 0.00965 | 0.05508 ± 0.01269 | 0.029 |
| Actinomyces | 0.00148 ± 0.00055 | 0.00673 ± 0.00159 | 0.002 |
| Megashaera | 0.00000 | 0.00631 ± 0.00287 | 0.027 |
| Lachnospiraceae_ [G-3] | 0.00059 ± 0.00033 | 0.00417 ± 0.00097 | 0.001 |
| Lachnoanaerobaculum | 0.00024 ± 0.00019 | 0.00123 ± 0.00033 | 0.008 |
| Eubacterium_[XIVa][G-1] | 0.00025 ± 0.00018 | 0.00109 ± 0.00031 | 0.019 |
| Ruminococcaceae_[G-3] | 0.00002 ± 0.00776 | 0.00119 ± 0.00448 | 0.016 |
| Bacteroides | 0.00000 | 0.00049 ± 0.00019 | 0.012 |
| Veillonella | 0.00000 | 0.00053 ± 0.00025 | 0.031 |
| Bacteroidetes_[G-3] | 0.00000 | 0.00032 ± 0.00010 | 0.002 |
| Peptostreptococcaceae_[XI][G-4] | 0.00000 | 0.00023 ± 0.00011 | 0.034 |
| Mitsuokella | 0.00000 | 0.00033 ± 0.00016 | 0.038 |
| Desulfovibrio | 0.00000 | 0.00405 ± 0.00040 | 0.018 |
| Catonella | 0.00000 | 0.00015 ± 0.00013 | 0.048 |
| Species | |||
| Streptococcus sp._str._C300 | 0.12958 ± 0.03003 | 0.03065 ± 0.00618 | 0.001 |
| Streptococcus multispecies_spp24_2 | 0.11555 ± 0.05022 | 0.00877 ± 0.00349 | 0.031 |
| Fusobacterium nucleatum_ss_animalis | 0.02401 ± 0.01178 | 0.00083 ± 0.00038 | 0.046 |
| Gemella haemolysans | 0.01308 ± 0.00599 | 0.00132 ± 0.00047 | 0.047 |
| Capnocytophaga ochracea | 0.00112 ± 0.00035 | 0.00004 ± 0.00002 | 0.023 |
| Veillonella parvula_group | 0.03273 ± 0.00653 | 0.10745 ± 0.01904 | 0.0003* |
| Prevotella melaninogenica | 0.02205 ± 0.00876 | 0.09752 ± 0.01762 | 0.0002* |
| Veillonella atypica | 0.00776 ± 0.00389 | 0.05509 ± 0.01369 | 0.001 |
| Neisseria flavescens/subflava | 0.01723 ± 0.00873 | 0.04995 ± 0.01204 | 0.023 |
| Porphyromonas gingivalis | 0.00000 | 0.02849 ± 0.01465 | 0.048 |
| Prevotella pallens | 0.00059 ± 0.00036 | 0.02308 ± 0.00617 | 0.0004* |
| Campylobacter concisus | 0.00133 ± 0.00083 | 0.01390 ± 0.00382 | 0.001 |
| Prevotella salivae | 0.00054 ± 0.00024 | 0.00848 ± 0.00293 | 0.006 |
| Prevotella veroralis_nov_95.28% | 0.00000 | 0.00723 ± 0.00287 | 0.010 |
| Solobacterium moorei | 0.00251 ± 0.00121 | 0.00638 ± 0.00154 | 0.045 |
| Megasphare micronuciformis | 0.00000 | 0.00631 ± 0.00287 | 0.023 |
| Atopobium parvulum | 0.00099 ± 0.00026 | 0.00579 ± 0.00223 | 0.028 |
| Lachnospiraceae_[G-3] sp._oral_taxon_100_nov_83.29% | 0.00049 ± 0.00032 | 0.00342 ± 0.00082 | 0.001 |
| Actinomyces sp._Oral_Taxon_180 | 0.00043 ± 0.00022 | 0.00328 ± 0.00103 | 0.006 |
| Actinomyces odontolyticus | 0.00047 ± 0.00015 | 0.00247 ± 0.00062 | 0.001 |
| Prevotella multispecies_sppn1_2_nov_82.34% | 0.00027 ± 0.00019 | 0.00158 ± 0.00579 | 0.026 |
| Lachnoanaerobaculum orale | 0.00024 ± 0.00019 | 0.00123 ± 0.00332 | 0.008 |
| Eubacterium_[XIVa][G-1] saburreum | 0.00025 ± 0.00018 | 0.00109 ± 0.00313 | 0.016 |
| Tannerella forsythia_nov_96.52% | 0.00000 | 0.00095 ± 0.00311 | 0.002 |
| Aggregatibacter aphrophilus | 0.00000 | 0.00080 ± 0.00035 | 0.018 |
| Porphyromonas gingivalis_nov_96.46% | 0.00000 | 0.00079 ± 0.00037 | 0.026 |
| Leptotrichia sp._oral_taxon_219_nov_83.33% | 0.00021 ± 0.00019 | 0.00077 ± 0.00020 | 0.039 |
| Fretibacterium fastidiosum | 0.00000 | 0.00074 ± 0.00033 | 0.019 |
| Ruminococcaceae_[G-3] sp._oral_taxon_366_nov_78.83% | 0.00002 ± 0.00002 | 0.00054 ± 0.00015 | 0.001 |
| Veillonella sp._oral_taxon_780_nov_82.14% | 0.00000 | 0.00053 ± 0.00025 | 0.029 |
| Mogibacterium neglectum | 0.00010 ± 0.00008 | 0.00051 ± 0.00190 | 0.044 |
| Haemophilus parainfluenzae_nov_96.89% | 0.00000 | 0.00043 ± 0.00026 | 0.018 |
| Desulfovibrio sp._oral_taxon_040 | 0.00000 | 0.00040 ± 0.00040 | 0.018 |
| Mitsuokella sp._Oral_Taxon_H31_nov_78.38% | 0.00000 | 0.00033 ± 0.00016 | 0.035 |
| Streptococcus constellatus_nov_80.22% | 0.00000 | 0.00032 ± 0.00013 | 0.008 |
| Porphyromonas gingivalis_nov_91.05% | 0.00004 ± 0.00004 | 0.00032 ± 0.00011 | 0.019 |
| Bacteroidetes_[G-3] sp._oral_taxon_280_nov_92.66% | 0.00000 | 0.00031 ± 0.00010 | 0.015 |
| Alloprevotella rava_nov_86.47% | 0.00000 | 0.00029 ± 0.00009 | 0.002 |
| Fretibacterium sp._oral_taxon_359 | 0.00000 | 0.00025 ± 0.00016 | 0.029 |
| Prevotella sp._oral_taxon_515_nov_80.56% | 0.00000 | 0.00024 ± 0.00013 | 0.018 |
| Prevotella sp._oral_taxon_515_nov_78.25% | 0.00000 | 0.00023 ± 0.00016 | 0.029 |
| Peptostreptococcaceae_[XI][G-4] sp._oral_taxon_369 | 0.00000 | 0.00022 ± 0.00011 | 0.031 |
| Catonella sp._oral_taxon_164_nov_95.73% | 0.00000 | 0.00015 ± 0.00014 | 0.048 |