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. 2018 Feb 26;8:3643. doi: 10.1038/s41598-018-22033-1

Table 6.

Values at 37 °C and 41 °C based on Q10 and Arrhenius Calculations.

Condition 37 °C
(Q 10 ) 		41 °C
(Q 10 ) 		37 °C
(Arrhenius) 		41 °C
(Arrhenius)
Peak GV Density (nS/pF)
WT - 0 nM Ca2+ - 0 µM Ran 16179.18 55592.62 8124.68 10881.05
WT - 0 nM Ca2+ - 10 µM Ran 22678.58 99329.99 9107.70 11251.36
WT - 2500 nM Ca2+ - 0 µM Ran 27586.50 131656.89 9377.01 11024.82
WT - 2500 nM Ca2+ - 10 µM Ran 15043.82 48489.81 6439.00 6969.03
EK - 0 nM Ca2+ - 0 µM Ran 3575.20 3527.30 3569.09 3525.15
EK - 0 nM Ca2+ - 10 µM Ran 12400.15 35482.80 5731.14 6055.55
EK - 2500 nM Ca2+ - 0 µM Ran 14940.82 51538.73 6366.24 7251.15
EK - 2500 nM Ca2+ - 10 µM Ran 2860.49 2527.87 2816.21 2513.95
Peak I Na Density (pA/pF)
WT - 0 nM Ca2+ - 0 µM Ran 446.63 597.28 463.00 604.67
WT - 0 nM Ca2+ - 10 µM Ran 564.39 706.75 580.56 713.78
WT - 2500 nM Ca2+ - 0 µM Ran 623.14 754.26 637.95 760.26
WT - 2500 nM Ca2+ - 10 µM Ran 521.76 633.36 534.72 638.92
EK - 0 nM Ca2+ - 0 µM Ran 270.93 288.18 272.97 288.90
EK - 0 nM Ca2+ - 10 µM Ran 339.21 361.89 341.86 362.80
EK - 2500 nM Ca2+ - 0 µM Ran 430.22 549.75 443.92 556.03
EK - 2500 nM Ca2+ - 10 µM Ran 222.38 215.51 221.51 215.22
Late I Na Density (pA/pF)
WT - 0 nM Ca2+ - 0 µM Ran 6.48 8.89 6.74 9.01
WT - 0 nM Ca2+ - 10 µM Ran 11.26 19.76 12.09 20.26
WT - 2500 nM Ca2+ - 0 µM Ran 11.08 11.77 11.17 11.80
WT–2500 nM Ca2+ - 10 µM Ran 8.17 10.02 8.38 10.11
EK - 0 nM Ca2+ - 0 µM Ran 29.25 56.02 31.75 57.68
EK - 0 nM Ca2+ - 10 µM Ran 4.15 4.58 4.20 4.60
EK - 2500 nM Ca2+ - 0 µM Ran 11.61 12.41 11.71 12.45
EK - 2500 nM Ca2+ - 10 µM Ran 13.12 18.37 13.69 18.65
Late Percent (%)
WT - 0 nM Ca2+ - 0 µM Ran 1.54 1.50 1.53 1.49
WT - 0 nM Ca2+ - 10 µM Ran 2.27 3.71 2.41 3.79
WT - 2500 nM Ca2+ - 0 µM Ran 2.80 2.91 2.81 2.92
WT - 2500 nM Ca2+ - 10 µM Ran 1.18 1.30 1.19 1.31
EK - 0 nM Ca2+ - 0 µM Ran 11.64 16.17 12.13 16.41
EKv0 nM Ca2+ - 10 µM Ran 0.92 1.00 0.93 1.00
EK - 2500 nM Ca2+ - 0 µM Ran 1.86 1.69 1.84 1.69
EK - 2500 nM Ca2+ - 10 µM Ran 3.94 4.96 4.05 5.01
GV-V 1/2 (mV)
WT - 0 nM Ca2+ - 0 µM Ran −44.27 −45.34 −44.40 −45.39
WT - 0 nM Ca2+ - 10 µM Ran −36.12 −33.96 −35.84 −33.87
WT - 2500 nM Ca2+ - 0 µM Ran −40.20 −39.68 −40.13 −39.66
WT - 2500 nM Ca2+ - 10 µM Ran −36.50 −34.66 −36.26 −34.58
EK - 0 nM Ca2+ - 0 µM Ran −29.04 −27.61 −28.86 −27.56
EK - 0 nM Ca2+ - 10 µM Ran −37.06 −37.39 −37.10 −37.40
EK - 2500 nM Ca2+ - 0 µM Ran −33.62 −32.25 −33.44 −32.19
EK - 2500 nM Ca2+ - 10 µM Ran −30.35 −29.25 −30.21 −29.21
GV-z
WT - 0 nM Ca2+ - 0 µM Ran 6.79 7.93 6.92 7.99
WT - 0 nM Ca2+ - 10 µM Ran 4.84 4.71 4.82 4.71
WT - 2500 nM Ca2+ - 0 µM Ran 6.59 7.49 6.70 7.53
WT - 2500 nM Ca2+ - 10 µM Ran 5.55 6.11 5.62 6.13
EK - 0 nM Ca2+ - 0 µM Ran 3.89 4.17 3.93 4.19
EK - 0 nM Ca2+ - 10 µM Ran 4.68 5.21 4.75 5.23
EK - 2500 nM Ca2+ - 0 µM Ran 4.36 4.78 4.41 4.80
EK - 2500 nM Ca2+ - 10 µM Ran 4.28 4.78 4.34 4.80
SSFI-V 1/2 (mV)
WT - 0 nM Ca2+ - 0 µM Ran −78.24 −75.70 −77.91 −75.59
WT - 0 nM Ca2+ - 10 µM Ran −81.49 −80.21 −81.32 −80.15
WT - 2500 nM Ca2+ - 0 µM Ran −77.46 −74.07 −77.02 −73.92
WT - 2500 nM Ca2+ - 10 µM Ran −81.11 −78.58 −80.79 −78.47
EK - 0 nM Ca2+ - 0 µM Ran −88.67 −85.79 −88.30 −85.67
EK - 0 nM Ca2+–10 µM Ran −92.87 −91.23 −92.66 −91.15
EK - 2500 nM Ca2+ - 0 µM Ran −95.62 −94.16 −95.43 −94.10
EK - 2500 nM Ca2+ - 10 µM Ran −93.54 −91.72 −93.31 −91.64
SSFI-z
WT - 0 nM Ca2+ - 0 µM Ran −4.95 −5.26 −4.99 −5.27
WT - 0 nM Ca2+ - 10 µM Ran −4.02 −4.04 −4.02 −4.04
WT - 2500 nM Ca2+ - 0 µM Ran −4.41 −4.63 −4.44 −4.63
WT - 2500 nM Ca2+ - 10 µM Ran −4.02 −4.05 −4.03 −4.05
EK - 0 nM Ca2+ - 0 µM Ran −3.24 −3.31 −3.25 −3.32
EK - 0 nM Ca2+ - 10 µM Ran −3.21 −3.30 −3.22 −3.31
EK - 2500 nM Ca2+ - 0 µM Ran −3.31 −3.38 −3.32 −3.38
EK - 2500 nM Ca2+ - 10 µM Ran −2.90 −2.85 −2.89 −2.84
−50mV FI τ (ms)
WT - 0 nM Ca2+ - 0 µM Ran 2.04 1.77 2.00 1.76
WT - 0 nM Ca2+ - 10 µM Ran 2.71 2.58 2.69 2.57
WT - 2500 nM Ca2+ - 0 µM Ran 2.19 1.92 2.15 1.91
WT - 2500 nM Ca2+ - 10 µM Ran 1.27 1.01 1.24 1.00
EK - 0 nM Ca2+ - 0 µM Ran 0.80 0.69 0.78 0.69
EK - 0 nM Ca2+ - 10 µM Ran 0.77 0.65 0.75 0.64
EK - 2500 nM Ca2+ - - 0 µM Ran 0.60 0.57 0.59 0.57
EK - 2500 nM Ca2+ - 10 µM Ran 1.04 0.99 1.03 0.99
−30mV FI τ (ms)
WT–0 nM Ca2+ - 0 µM Ran 0.54 0.43 0.53 0.43
WT - 0 nM Ca2+–10 µM Ran 0.61 0.52 0.60 0.52
WT - 2500 nM Ca2+ - 0 µM Ran 0.36 0.26 0.35 0.25
WT - 2500 nM Ca2+ - 10 µM Ran 0.51 0.42 0.50 0.42
EK - 0 nM Ca2+ - 0 µM Ran 0.30 0.25 0.29 0.25
EK - 0 nM Ca2+ - 10 µM Ran 0.26 0.21 0.25 0.21
EK - 2500 nM Ca2+ - 0 µM Ran 0.23 0.20 0.23 0.20
EK - 2500 nM Ca2+ - 10 µM Ran 0.31 0.27 0.31 0.27
−10mV FI τ (ms)
WT - 0 nM Ca2+ - 0 µM Ran 0.28 0.22 0.27 0.21
WT - 0 nM Ca2+ - 10 µM Ran 0.30 0.25 0.29 0.25
WT - 2500 nM Ca2+ - 0 µM Ran 0.21 0.16 0.20 0.15
WT–2500 nM Ca2+ - 10 µM Ran 0.24 0.19 0.23 0.19
EK - 0 nM Ca2+ - 0 µM Ran 0.20 0.16 0.19 0.16
EK - 0 nM Ca2+ - 10 µM Ran 0.18 0.15 0.18 0.15
EK - 2500 nM Ca2+ - 0 µM Ran 0.15 0.13 0.15 0.13
EK - 2500 nM Ca2+ - 10 µM Ran 0.19 0.16 0.18 0.16
 +10 mV FI τ (ms)
WT - 0 nM Ca2+ - 0 µM Ran 0.19 0.14 0.18 0.14
WT - 0 nM Ca2+ - 10 µM Ran 0.20 0.16 0.19 0.16
WT - 2500 nM Ca2+ - 0 µM Ran 0.16 0.12 0.16 0.12
WT - 2500 nM Ca2+ - 10 µM Ran 0.16 0.13 0.16 0.12
EK - 0 nM Ca2+ - 0 µM Ran 0.16 0.13 0.15 0.13
EK - 0 nM Ca2+ - 10 µM Ran 0.15 0.12 0.14 0.12
EK - 2500 nM Ca2+ - 0 µM Ran 0.12 0.10 0.12 0.10
EK - 2500 nM Ca2+ - 10 µM Ran 0.15 0.12 0.14 0.12
1 Hz-y0
WT - 0 nM Ca2+ - 0 µM Ran 0.94 0.97 0.94 0.97
WT - 0 nM Ca2+ - 10 µM Ran 0.76 0.76 0.76 0.76
WT - 2500 nM Ca2+ - 0 µM Ran 0.90 0.93 0.90 0.93
WT - 2500 nM Ca2+ - 10 µM Ran 0.83 0.85 0.84 0.85
EK - 0 nM Ca2+ - 0 µM Ran 0.86 0.92 0.87 0.92
EK - 0 nM Ca2+ - 10 µM Ran 0.83 0.91 0.84 0.92
EK - 2500 nM Ca2+ - 0 µM Ran 0.92 0.97 0.92 0.97
EK - 2500 nM Ca2+ - 10 µM Ran 0.83 0.90 0.84 0.91
1 Hz-τ1 (s)
WT - 0 nM Ca2+ - 0 µM Ran 5.34 6.15 5.43 6.18
WT - 0 nM Ca2+ - 10 µM Ran 6.34 7.76 6.51 7.83
WT - 2500 nM Ca2+ - 0 µM Ran 42.49 65.65 44.88 66.93
WT - 2500 nM Ca2+ - 10 µM Ran 2.23 1.65 2.15 1.63
EK - 0 nM Ca2+ - 0 µM Ran 8.14 10.28 8.38 10.38
EK - 0 nM Ca2+ - 10 µM Ran 2.22 2.01 2.19 2.00
EK - 2500 nM Ca2+ - 0 µM Ran 25.75 50.72 28.04 52.25
EK - 2500 nM Ca2+ - 10 µM Ran 1.22 0.77 1.15 0.75
1 Hz-τ2 (s)
WT - 0 nM Ca2+ - 0 µM Ran 37.43 35.07 37.13 34.97
WT - 0 nM Ca2+ - 10 µM Ran 86.46 129.96 91.00 132.31
WT - 2500 nM Ca2+ - 0 µM Ran 50.52 40.70 49.16 40.30
WT - 2500 nM Ca2+ - 10 µM Ran 81.65 104.69 84.25 105.85
EK - 0 nM Ca2+ - 0 µM Ran 68.52 68.34 68.50 68.33
EK - 0 nM Ca2+ - 10 µM Ran 82.26 87.65 82.91 87.89
EK - 2500 nM Ca2+ - 0 µM Ran 79.80 102.18 82.29 103.26
EK - 2500 nM Ca2+ - 10 µM Ran 43.43 37.52 42.64 37.27
3 Hz-y0
WT - 0 nM Ca2+ - 0 µM Ran 0.90 0.99 0.91 1.00
WT - 0 nM Ca2+ - 10 µM Ran 0.69 0.75 0.70 0.75
WT - 2500 nM Ca2+ - 0 µM Ran 0.83 0.88 0.84 0.88
WT - 2500 nM Ca2+ - 10 µM Ran 0.63 0.65 0.63 0.66
EK - 0 nM Ca2+ - 0 µM Ran 0.79 0.82 0.79 0.83
EK - 0 nM Ca2+ - 10 µM Ran 0.57 0.60 0.57 0.60
EK - 2500 nM Ca2+ - 0 µM Ran 0.76 0.78 0.76 0.78
EK - 2500 nM Ca2+ - 10 µM Ran 0.68 0.76 0.69 0.76
3 Hz-τ1 (s)
WT - 0 nM Ca2+ - 0 µM Ran 2.97 3.29 3.01 3.30
WT - 0 nM Ca2+ - 10 µM Ran 0.70 0.46 0.67 0.46
WT - 2500 nM Ca2+ - 0 µM Ran 1.38 1.28 1.36 1.27
WT - 2500 nM Ca2+ - 10 µM Ran 0.98 0.93 0.97 0.92
EK - 0 nM Ca2+ - 0 µM Ran 3.07 3.69 3.14 3.72
EK - 0 nM Ca2+ - 10 µM Ran 1.47 1.29 1.45 1.28
EK - 2500 nM Ca2+ - 0 µM Ran 2.27 2.01 2.24 2.00
EK - 2500 nM Ca2+ - 10 µM Ran 0.84 0.58 0.81 0.57
3 Hz-τ2 (s)
WT - 0 nM Ca2+ - 0 µM Ran 14.24 10.80 13.75 10.66
WT - 0 nM Ca2+ - 10 µM Ran 15.28 13.72 15.08 13.65
WT - 2500 nM Ca2+ - 0 µM Ran 39.52 40.39 39.63 40.43
WT - 2500 nM Ca2+ - 10 µM Ran 20.81 26.32 21.43 26.60
EK - 0 nM Ca2+ - 0 µM Ran 54.26 61.55 55.14 61.90
EK - 0 nM Ca2+ - 10 µM Ran 31.12 36.95 31.81 37.24
EK - 2500 nM Ca2+ - 0 µM Ran 43.81 68.26 46.41 69.75
EK - 2500 nM Ca2+ - 10 µM Ran 5.29 4.15 5.13 4.11