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. 2018 Feb 14;14:407–415. doi: 10.3762/bjoc.14.29

Scheme 2.

Scheme 2

Synthesis of cyclo[DKP-isoDGR]-PEG-4-Val-Ala-α-amanitin conjugate 11. Reagents and conditions: a) 4-pentynoic acid N-hydroxysuccinimidyl ester, iPr2NEt, DMF, overnight; b) N3-PEG-4-cyclo[DKP-isoDGR], sodium ascorbate, CuSO4·5H2O, DMF/water, rt, overnight.