Figure 1. . Schematic illustration of the two approaches to two-stage, pretargeting immunotherapy.

The bifunctional peptope or peptide binds amyloid via electrostatic interactions (1). The peptides serve as targets for antibodies that opsonize the deposits (2) subsequently recruiting macrophages capable of removing the amyloid (3).

mAb: Monoclonal antibody.

Data taken from [Wall et al., University of Tennessee Medical Center, Unpublished Data].