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. 2018 Feb 13;14:397–406. doi: 10.3762/bjoc.14.28

Table 1.

Assembly of trimers on soluble supports.

entry soluble support 5'-O-PG chemistry release conditions
1 graphic file with name Beilstein_J_Org_Chem-14-397-i001.jpg H phosphotriester TCEP, NEt3, MeOH,
3 h, 57%
2 graphic file with name Beilstein_J_Org_Chem-14-397-i002.jpg DMTr phosphotriester K2CO3,DCM/MeOH/
dioxane, 30 min, 88–99%
3 graphic file with name Beilstein_J_Org_Chem-14-397-i003.jpg DMTr phosphoramidite H2/Pd, THF, 40 h, 44–49%