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. 2017 Dec 4;13(28):2583–2592. doi: 10.2217/fon-2017-0343

Table 1. . The miRNAs carried by tumor-derived exosomes and delivered to immune cells induce protumorigenic functions.

miRNA carried by TEX Tumor type Recipient cell Acquired functions Consequences for recipient cells
miR-21 miR-29a NSLC TAMs Inline graphicNF-κB pathway  
      Inline graphicIL-6, Inline graphicTNF-α Inline graphicProinflammatory phenotype
miR-203
miR-212p		 PAC DCs Inline graphicTLR-4
Inline graphicTNF-α, Inline graphic IL-12		 Inline graphicDC maturation
Inline graphicDC dysfunction
miR-214 Various human or mouse tumors T cells Inline graphicTreg
Inline graphicPTEN
Inline graphicIL-10		 Inline graphicImmune  suppression
miR-183 Human tumor cell lines NK cells Inline graphicTGF-β
Inline graphicDAP12		 Inline graphicLytic functions
miR-92a Glioma NKT cells Inline graphicPerforin
Inline graphicFasL
Inline graphicIFN-γ
Inline graphicCD8+ T cells		 Inline graphicTumor apoptosisInline graphicAntitumor activity

Selected examples of miRNA interactions with different types of immune cells are presented. For a detailed review of TEX-associated miRNAs and their biological effects, see [34].

DC: Dendritic cell; NK: Natural killer; NSLC: Non-small-cell lung cancer; PAC: Pancreatic adenocarcinoma; TAM: Tumor-associated macrophage; TEX: Tumor-derived exosome.