Table 3.
Analgesic effect of PSDE and PSNH in tail immersion test.
| Group | Dose | Latency period (s) | ||||
|---|---|---|---|---|---|---|
| 0 min | +30 min | +60 min | +90 min | +120 min | ||
| Control | 10 mL/kg | 1.4680 ± 0.14 | 1.42 ± 0.29 | 1.41 ± 0.16 | 1.74 ± 0.16 | 1.20 ± 0.30 |
| TH | 10 mg/kg | 1.7020 ± 0.14 | 6.96 ± 1.50∗ | 6.68 ± 2.00∗ | 4.48 ± 2.19 | 4.07 ± 1.21∗ |
| PSDE | 200 mg/kg | 1.5180 ± 0.14 | 2.87 ± 0.33 | 3.74 ± 1.31 | 2.61 ± 0.62 | 2.06 ± 0.27 |
| PSDE | 400 mg/kg | 1.6540 ± 0.21 | 4.47 ± 0.67∗ | 3.75 ± 1.89 | 2.17 ± 0.25 | 2.64 ± 0.38 |
| PSNH | 200 mg/kg | 1.6540 ± 0.25 | 2.71 ± 0.52 | 2.01 ± 0.50 | 1.83 ± 0.14 | 1.77 ± 0.28 |
| PSNH | 400 mg/kg | 1.2920 ± 0.10 | 3.12 ± 0.63 | 2.56 ± 0.30 | 2.41 ± 0.13 | 2.07 ± 0.11 |
Latency period evaluated from this study is represented as mean ± SEM. 0 min indicates 30 min before treatment and +30, +60, +90, and +120 mean after 30 min, 60 min, 90 min, and 120 min of treatment, respectively. Tests of within-subjects effects reveal that for the factor “time” calculated F = 9.30 for all methods and P value = 0.000 in every case. So, time is highly significant at any level of significance. ∗P < 0.05, versus control. Repeated measure analysis of variance with Dunnett's multiple comparison was performed to analyze this data set.