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Signaling mechanisms and therapeutic targeting of SHP2 and PRLs. A, The schematic structure of SHP2, strategies of targeting SHP2 for cancer therapy, and the latest small-molecule SHP2 inhibitors. B, SHP2 promotes multiple oncogenic signaling pathways. C, PRL-mediated signaling in cancer. D, Strategies of targeting PRLs for cancer therapy and representative PRL inhibitors. EMT, epithelial–mesenchymal transition.
