Table 1.
Demographic summary and baseline characteristics for surgery and control participants
| Demographic | Surgery (n = 48) Mean±SD or %(n) |
Control (n = 45) Mean±SD or %(n) |
|---|---|---|
|
| ||
| Age | 67.81±5.62 (range: 60–84) | 69.02±5.81 (range: 60–83) |
| Education | 15.21±2.79 (range: 11–23) | 16.29±2.67 (range: 9–24) |
| Sex (M:F) | 20:28 | 21:24 |
| TICS | 37.38±3.81 (range: 26–47)* | 38.60±3.12 (range: 32–45) |
| Pre-morbid Cognitive Reserve | 0.56±0.52 (range: −0.49–1.62)* | 1.00±0.48 (range: −0.60–1.77) |
| Working Memory | 0.51±0.73 (range: −1.18–2.20) | 0.74±0.80 (range: −1.10–2.55) |
| Processing Speed | −0.05±0.55 (range: −1.27–1.29)* | 0.22±0.68 (range: −1.74–1.76) |
| Declarative Memory | 0.21±0.74 (range: −1.42–1.36)* | 0.81±0.79 (range: −1.33–1.82) |
| Ventricle Volume | 29669.13±14542.14 (range: 9452.6–67240) | 29339.57±14497.10 (range: 9065.8–69274.7) |
| TICV | 1.54×106±1.47×105 (range: 1.29×106–1.89×106) | 1.56×106±1.46×105 (range: 1.27×106–1.89×106) |
| PreMRI Pain | 11.90±18.02 (range: 0–65) | 5.70±11.95 (range: 0–50) |
| PostMRI Pain | 36.08±22.02 (range: 2–100)* | 5.77±8.94 (range: 0–40) |
| MED | 10.68±10.67 (range: 0–37.50) | -- |
| PrePost MRI day span | 8.50±5.68 (range: 3–41) | 7.40±3.14 (range: 2–21) |
Indicates group difference p < 0.05.
TICS: Telephone Interview for Cognitive Status [31, 32]. Pre-morbid Cognitive Reserve: Composite of Vocabulary (from the Wechsler Abbreviated Scale of Intelligence) and Wide Range Achievement Test. Working Memory: Composite score of Digit Span backward, Letter-Number Sequencing, and Spatial Span backward. Processing Speed: Composite score of Digit Symbol total, Stroop word reading, and Trail Making Test Part A total time. Declarative Memory: Composite score of HVLT delay recall and recognition and WMS Logical Memory delay recall. Composite scores are based on published normative samples. Ventricle Volume: sum of left and right lateral ventricle volumes in mm3. TICV = Total Intracranial Volume in mm3. PreMRI Pain: 0–100 pain score acquired just before the pre-surgery resting state fMRI scan. PostMRI Pain: 0–100 pain score acquired just before the post-surgery resting state fMRI scan. MED: Morphine Equivalence Dose calculated using CDC guidelines [44]. PrePost MRI day span: time in days between pre and post MRI scans.