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. Author manuscript; available in PMC: 2018 Feb 27.
Published in final edited form as: Sci Signal. 2017 Dec 12;10(509):eaan6282. doi: 10.1126/scisignal.aan6282

Figure 8. Relationship between serum CRP level and osteolytic bone lesion number in patients with newly diagnosed myeloma.

Figure 8

(A) Correlation between serum CRP level and the number of lytic bone lesions in 244 patients with newly diagnosed myeloma. CRP was measured by ELISA, and bone lesions were detected by radiography (x-ray or MRI). (B) Representative images of immunohistochemical staining for CRP accumulation in the bone marrow of myeloma patients (3 per group) with low (BL < 3) or high (BL ≥ 6) numbers of bone lesions. Scale bar, 50 μM. (C–E) Correlations between the level of circulating CRP and (C) MCP-1, (D) RANKL, and (E) CTx-1 in 28 randomly selected patients with newly diagnosed myeloma, calculated by Pearson’s correlation coefficient analysis.