Fig. 7.

Photoactivation of internalized nanoparticles only decreases breast and prostate cancer cell viability in vitro. TRAMP-C1 and PyMT-R221A cells were grown, treated with varying concentration of nanoparticles for 24 h. Cell monolayers were then washed to keep only the internalized nanoparticles (empty square) in culture or not washed, keeping all nanoparticles (filled circle), internalized and non-internalized in culture. Culture plates were then irradiated with different dose of UV (0–2 J/cm²). Toxicity was analyzed by MTT assay 24 h after UV exposure. Results are expressed as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 using a 2-way ANOVA with a Sidak posttest