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Hypothesis on the production of anti-TIF1γ/α antibodies based on mutation of TIF1γ or interaction of viral proteins with TIF1. In old adult DM patients with malignancy, TIF1γ mutation may allow development of malignancy while the mutated protein may also trigger autoimmune response to TIF1γ. In JDM or young adult DM patients, interaction of viral proteins with TIF1 proteins may create cryptic epitopes, leading to the autoimmune response
