. Author manuscript; available in PMC: 2018 Feb 27.

Published in final edited form as: Clin Rev Allergy Immunol. 2017 Feb;52(1):1–19. doi: 10.1007/s12016-015-8510-y

Table 1.

Myositis-specific and myositis-associated autoantibodies

Type of autoantibodies	Myositis-specific antibodies (MSA)	Myositis-associated antibodies (MAA)	Other autoantibodies often found in myositis
Autoantibody specificities	Classic MSA: Jo-1, PL-7, PL-12, EJ, OJ, Mi-2, SRP New antibodies that can be considered MSA: KS, TIF1γ/α, TIF1β, MJ/NXP-2, MDA5/CADM-140, SAE	PM-Scl, Ku, U1RNP, U1/U2RNP, U3RNP	Ro52, Ro60, Su/Ago2
Association with SARD	PM/DM, PM/DM-overlap syndrome	PM/DM, PM/DM-overlap syndrome, SSc, SLE	Various SARD
Detection in non-PM/DM	Uncommon (anti-ARS can be in overlap syndrome and idiopathic ILD)	Not uncommon	Often
Association with myopathy when found in non-PM/DM	Yes	Yes	No or not established
Prevalence In general population [20]	Almost none	PM-Scl, Ku, U1/U2RNP—almost none; U1RNP, ~0.1 %	Relatively common (0.5–1 %)

SARD systemic autoimmune rheumatic diseases, PM polymyositis, DM dermatomyositis, SSc scleroderma, systemic sclerosis, SLE systemic lupus erythematosus, ILD interstitial lung disease