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. Author manuscript; available in PMC: 2018 Feb 27.
Published in final edited form as: Clin Rev Allergy Immunol. 2017 Feb;52(1):1–19. doi: 10.1007/s12016-015-8510-y

Table 2.

Target autoantigens of myositis-specific autoantibodies

Autoantibodies Target molecule Function Protein RNA
Aminoacyl tRNA synthetase
 Jo-1 Histidyl tRNA synthetase Incorporate histidine into proteins 50 kD tRNAhis
 PL-7 Threonyl tRNA synthetase Incorporate threonine into proteins 80 kD tRNAthr
 PL-12 Alanyl tRNA synthetase Alanine and aspartate biosynthesis and alanine incorporation into proteins 110 kD tRNAala
 EJ Glycyl tRNA synthetase Glycine, serine and threonine metabolism, and aminoacyl tRNA biosynthesis 75 kD tRNAgly
 OJ Isoleucyl tRNA synthetase Incorporate isoleucine into proteins 150 kD, (multienzyme complex, 170, 130, 75 kD) tRNAiso
 KS Asparaginyl tRNA synthetase Glutamate, alanine and aspartate metabolism 65 kD tRNAasp
 ZO Phenylalanyl tRNA synthetase Incorporate phenylalanine into proteins 60/70 kD tRNAphen
 YRS (HA) Tyrosyl tRNA synthetase Incorporate tyrosine into proteins 59 kD tRNAtyr
SRP Signal Recognition Particle Protein maturation in the ribosome 72, 68, 54, 19, 14, 9 kD 7SL RNA
Mi2 Helicase protein Transcriptional regulation 240, 150, 72, 65, 63, 50 and 34 kD –
MDA5 (CADM140) MDA5 (melanoma differentiation-associated gene 5) RNA-specific helicase that mediates the antiviral response 140 kD –
TIF1γ/α (p155/140, TRIM33/TRIM24) TIF1γ/α Transcription and RNA metabolism 155 and 140 kD –
TIF1β (TRIM28) TIF1β Transcription and RNA metabolism 120 kD –
MJ/NXP-2 NXP2 (MORC3) Transcriptional regulation and activation of the tumor suppressor p53 140 kD –
SAE Small ubiquitin-like modifier 1 (SUMO-1) activating enzyme Post-translational modifications 90 and 40 kD –

Modified from [30]