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. Author manuscript; available in PMC: 2018 Feb 27.
Published in final edited form as: Trends Genet. 2016 Oct 4;32(11):707–716. doi: 10.1016/j.tig.2016.09.002

Figure 2. Dynamic GATA4 genomic occupancy governs epigenetic and physiological states of cardiac biology.

Figure 2

A. In developing cardiomyocytes, GATA4 predominantly binds to distal enhancers of developmental genes and correlates with enrichment of H3K27 acetylation (green triangles on blue circles). Adult cardiac and non-cardiac genes, which are not expressed in developing cardiomyocytes, lack both GATA4 binding and H3K27 acetylation. B. Mature cardiomyocytes display a shift in both GATA4 occupancy and H3K27 acetylation from distal fetal enhancers to proximal adult enhancers. C. During disease states, GATA4 reactivates a subset of its developmental targets, but also binds and activates non-cardiac genes, implying that these novel targets contribute significantly to disease phenotypes.