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. Author manuscript; available in PMC: 2018 Feb 27.
Published in final edited form as: Trends Genet. 2016 Oct 4;32(11):707–716. doi: 10.1016/j.tig.2016.09.002

Figure 3. Relative binding site orientations influence activities of heterotypic transcription factor complexes.

Figure 3

A. The TBX5-GATA4-NKX2.5 complex binds to regulatory sequences in particular arrangements (e.g. proper combinations, spacing, head/tail orientations). Non-optimal binding sites are not occupied by the complex. B. Loss of complex members (e.g. GATA4-null cardiomyocytes) can redistribute remaining members to ectopic sites in the genome, leading to inappropriate gene expression and potentially exacerbating loss-of-function phenotypes.