Skip to main content
. Author manuscript; available in PMC: 2018 Feb 27.
Published in final edited form as: Trends Genet. 2016 Oct 4;32(11):707–716. doi: 10.1016/j.tig.2016.09.002

Figure 4. TBX5 promotes cardiac septation via NuRD-mediated transcriptional repression.

Figure 4

A. During cardiac development, TBX5 activates transcription of relevant downstream targets, including cardiomyocyte structural genes. At non-cardiac targets, TBX5 recruits the NuRD chromatin remodeling complex to inhibit lineage-inappropriate gene expression. Together, these functions allow for proper development and septation of the heart. B. Disruption of the TBX5-NuRD interaction (yellow star), either through disease mutations or evolutionary mechanisms, derepresses targets of TBX5-mediated repression, leading to congenital heart defects such as AVSDs.