Fig. 5.

CASC2 controlled AQP1 expression by regulating miR-144-3p. a The AQP1 mRNA expression level was decreased in LPS-induced A549 cell. Under LPS induced environment, transfection of pcDNA-CASC2 increased AQP1 mRNA expression level, while co-transfection of pcDNA-CASC2 and miR-144-3p mimic reversed the increased AQP1 mRNA expression level. b The AQP1 protein expression level in A549 cell were in accord with the mRNA expression. *P < 0.05 vs pcDNA, ^#P < 0.05 vs pcDNA-CASC2 + pre-NC, ^&P < 0.05 vs pcDNA-CASC2 + miR-144-3p mimic