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. 2018 Jan 31;9(12):10621–10634. doi: 10.18632/oncotarget.24360

Figure 3. Schematic depiction of microhemorrhage distribution within the spinal cord of G93A mice after cell transplantation.

Figure 3

The locations of microhemorrhages (*) within the C4-C6 (left) and L3-L5 (right) segments of the spinal cord of control (A), and media-treated (B), low (C), mid (D), and high (E) cell-dose G93A mice are topographically mapped on the C4 and L4 segments accordingly to the mouse spinal cord atlas. In media-treated mice (B), numerous microhemorrhages were determined in the gray matter of the cervical and lumbar spinal cords. In white matter, microhemorrhages localized to ascending and descending pathways in cervical and lumbar spinal cords. Microhemorrhages decreased in gray matter of mice inversely with cell dose (C-E) with the greatest reduction observed in cervical and lumbar spinal cords of high cell-dose mice. In white matter, dose-dependent decrease of microhemorrhages (C-E) was determined only in cervical descending pathway and lumbar lateral spiny nuclei of high cell-dose mice. VH: ventral horn, DH: dorsal horn, Lwm: lateral white matter, Awm: anterior white matter, Pwm: posterior white matter. Scale bar in spinal cord section is 5mm.