Table 1. Distribution of microhemorrhages in the cervical and lumbar spinal cords.
| Animal group | Average number of microhemorrhages ± S.E.M. | Number/percentage of microhemorrhages by spinal cord region | ||||
|---|---|---|---|---|---|---|
| Ventral horn | Dorsal horn | Lateral white matter | Anterior white matter | Posterior white matter | ||
| A. Cervical spinal cord | ||||||
| Control | 0.67 ± 0.33 | 2/50.0 | 0/0.0 | 1/25.0 | 1/25.0 | 0/0.0 |
| Media | 5.17 ± 1.19 | 11/35.5 | 7/22.6 | 5/16.1 | 7/22.6 | 1/3.2 |
| Low dose | 3.83 ± 0.98 | 7/30.5 | 5/21.7 | 5/21.7 | 5/21.7 | 1/4.4 |
| Mid dose | 3.17 ± 0.98 | 6/31.6 | 5/26.3 | 2/10.5 | 4/21.1 | 2/10.5 |
| High dose | 1.00 ± 0.63 | 2/33.3 | 0/0.0 | 1/16.7 | 0/0.0 | 3/50.0 |
| B. Lumbar spinal cord | ||||||
| Control | 0.50 ± 0.34 | 1/33.4 | 1/33.3 | 0/0.0 | 1/33.3 | 0/0.0 |
| Media | 6.50 ± 0.92 | 16/41.0 | 11/28.2 | 6/15.4 | 4/10.3 | 2/5.1 |
| Low dose | 3.67 ± 1.31 | 10/45.5 | 6/27.3 | 3/13.6 | 2/9.1 | 1/4.5 |
| Mid dose | 2.00 ± 1.06 | 4/33.3 | 3/25.0 | 3/25.0 | 2/16.7 | 0/0.0 |
| High dose | 1.17 ± 0.79 | 3/42.8 | 2/28.6 | 2/28.6 | 0/0.0 | 0/0.0 |
In the cervical (A) and lumbar (B) spinal cords of media-treated mice, higher numbers of microhemorrhages were determined in the ventral and dorsal horns compared to white matter areas. Cell-transplanted mice demonstrated a similar distribution pattern to media-treated mice with a substantial reduction of microhemorrhages in the spinal cords of ALS mice receiving the high cell-dose. No microhemorrhages were detected in cervical dorsal horn, cervical anterior white matter, lumbar anterior white matter, or lumbar posterior white matter in high cell-dose mice.