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. 2017 Dec 28;9(12):10375–10387. doi: 10.18632/oncotarget.23735

Figure 5. IGF-1R inhibition but not ROCK inhibition reduces the incidence of lung metastasis without affecting tumor growth in breast cancer xenografts.

Figure 5

(A) MDA-MB-231 cells were implanted in the mammary fat pad of SCID mice and treated with PQ401, Y27632 or PQ401 combined with Y27632. IGF-1R and ROCK inhibition did not affect primary tumor growth. (B–C) Five weeks after primary tumor resection, lungs of MDA-MB-231 tumor bearing mice were collected and analyzed for lung metastasis. PQ401 decreased non-significantly the metastasis burden in lungs, but significantly decreased the incidence of lung metastasis. Y27632 alone or combined with PQ401 significantly increased the lung metastasis burden.