FIGURE 5. Blockade of NKG2D–H60a interaction during NOD CTL differentiation results in increased CTL effector cytokine production.

Secretion of TNF-α, IFN-γ, and IL-10 by in vitro–generated Klrk1^−/− and wild-type CTL stimulated with the indicated concentrations of anti-CD3ε Ab in the presence of an anti-H60a or isotype control Ab. Data are representative of at least six independent experiments. *p ≤ 0.05, ***p ≤ 0.001, ****p ≤ 0.0001 in two-tailed unpaired Mann–Whitney U test.