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. 2017 Dec 15;27:214–224. doi: 10.1016/j.ebiom.2017.12.013

Fig. 2.

Fig. 2

Analysis of plasma lipids, oral fat load, VLDL secretion and post-heparin plasma LPL activity. (a–c) Plasma TC, TG and HDL-C of the chow diet-fed male hamsters at 8–10 weeks of age (n = 8 to 16 per group). (d) FPLC analysis of the lipoprotein distribution in pooled plasma from normal and Ldlr-mutated humans, mice and hamsters on a regular chow diet (5–6 animals, mixed sex). (e) Oral fat load was assessed in 8–10 weeks old male hamsters on a regular chow diet that were fasted for 12 h and gavaged with olive oil at 10 mL/kg body weight. Plasma was collected at different time points for TG measurements (n = 6 per group). (f) VLDL secretion was conducted in the 12-h fasted 8–10 weeks old male animals on a regular chow diet by injecting 1500 mg/kg poloxamer. Plasma was collected at the indicated time points for TG assays (n = 6 per genotype). (g) Post-heparin plasma LPL activity in the 8–10 weeks old WT and Ldlr −/− hamsters with chow diet feeding. LPL activity was measured using blood on ice that was collected10 min after an intravenous injection of 100 U/kg heparin (n = 6 per genotype). All data are expressed as the mean ± SEM. ** denotes p < 0.01 vs WT hamsters. ## denotes p < 0.01 vs Ldlr +/− hamsters.