Figure 1.

Na_V1.7 variants identified in study participants with painful diabetic peripheral neuropathy. (A) Schematic of Na_V1.7 channel topology. The variants previously reported in the literature as associated with painful neuropathy are represented with blue dots and the newly identified variants with red ones. (B) Sequence alignment of human Na_V1.1-Na_V1.9 channels and of Na_V1.7 channel in different species showing the conserved M1852 amino acid in red. (C) Sequence alignment of human Na_V1.1-Na_V1.9 channels and of Na_V1.7 channel in different species showing the conserved T1596 amino acid in red.