Table 1.
Enriched metabolic pathway in the coexpression network.
| Term | Count | Pop | P value | Genes |
|---|---|---|---|---|
| hsa00230: purine metabolism | 17 | 176 | 8.46E − 11 | 5427, 9533, 2618, 6240, 5557, 11164, 6241, 26289, 270, 158, 93034, 8833, 10606, 471, 108, 107, 2983 |
| hsa01130: biosynthesis of antibiotics | 14 | 212 | 6.52E − 07 | 6120, 5224, 5232, 5223, 230, 2618, 26289, 270, 158, 8789, 92483, 10606, 471, 2027 |
| hsa00240: pyrimidine metabolism | 10 | 104 | 2.40E − 06 | 93,034, 5427, 9533, 7372, 7371, 6240, 5557, 7298, 6241, 7083 |
| hsa00010: glycolysis/gluconeogenesis | 7 | 67 | 1.06E − 04 | 92483, 5224, 5232, 5223, 230, 2027, 8789 |
| hsa00670: one carbon pool by folate | 4 | 20 | 0.001425311 | 1719, 471, 2618, 7298 |
| hsa01230: biosynthesis of amino acids | 6 | 74 | 0.001495954 | 6120, 5224, 5232, 5223, 230, 2027 |
| hsa01200: carbon metabolism | 7 | 113 | 0.001764573 | 6120, 5224, 5232, 5223, 230, 2027, 8789 |
| hsa04913: ovarian steroidogenesis | 5 | 49 | 0.002269906 | 1583, 108, 107, 3284, 1588 |
| hsa00330: arginine and proline metabolism | 5 | 50 | 0.002446109 | 84735, 1158, 4842, 57571, 1160 |
| hsa00140: steroid hormone biosynthesis | 5 | 58 | 0.004206383 | 1583, 1589, 3284, 1588, 1584 |
| hsa00410: beta-alanine metabolism | 4 | 31 | 0.005135035 | 84735, 2572, 57571, 8639 |
| hsa00514: other types of O-glycan biosyntheses | 4 | 31 | 0.005135035 | 10690, 135152, 27087, 23127 |
| hsa00061: fatty acid biosynthesis | 3 | 13 | 0.00927769 | 23205, 81616, 23305 |
| hsa00790: folate biosynthesis | 3 | 14 | 0.010744279 | 5860, 1719, 8836 |
| hsa04925: aldosterone synthesis and secretion | 5 | 81 | 0.013544109 | 1583, 108, 107, 1589, 3284 |
| hsa00983: drug metabolism—other enzymes | 4 | 46 | 0.015345429 | 8833, 7372, 7371, 7083 |
| hsa01212: fatty acid metabolism | 4 | 48 | 0.017202919 | 23205, 79966, 81616, 23305 |
| hsa04922: glucagon signaling pathway | 5 | 99 | 0.026291005 | 92483, 5224, 5223, 5837, 108 |
| hsa00534: glycosaminoglycan biosynthesis—heparan sulfate/heparin | 3 | 24 | 0.030276378 | 222537, 9348, 266722 |
| hsa03320: PPAR signaling pathway | 4 | 67 | 0.040871389 | 23205, 79966, 81616, 23305 |
| hsa00030: pentose phosphate pathway | 3 | 29 | 0.042939357 | 6120, 230, 8789 |
| hsa00760: nicotinate and nicotinamide metabolism | 3 | 29 | 0.042939357 | 93034, 27231, 23057 |