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. 2018 Feb 14;14(2):e1007210. doi: 10.1371/journal.pgen.1007210

Fig 2. Ophthalmological data.

Fig 2

A. Family 1a IV:1 Upper line: Fundus oculi pictures show bilateral optic nerve pallor. Middle line: Computerized visual fields (VFs) (pattern deviation) reveal bilateral generalized defect. Lower line: Optical coherence tomography (OCT) (Cirrus, Zeiss) demonstrates bilateral diffuse optic atrophy with relative nasal sparing. B. Family 1b V:6 Upper line: Fundus oculi pictures show normal optic nerve in OD and mild temporal pallor in OS. Middle line: Computerized VFs is unremarkable in OD and demonstrates a small central scotoma in OS. Lower line: OCT demonstrates normal retinal nerve fiber layer thickness in OD and temporal thinning in OS (Spectralis, Heidelberg). C. Family 2 IV:2 Upper line: Fundus oculi pictures show bilateral optic nerve pallor. Middle line: Computerized VFs reveal bilateral central scotoma. Lower line: OCT demonstrates bilateral diffuse optic atrophy with relative nasal sparing (Cirrus, Zeiss).