Table 3.

Associations between COX expression levels and ovarian cancer survival, the Vanderbilt TROC

	Disease-free survival (DFS), hazard ratio (95% CI), P-value						Overall survival (OS), hazard ratio (95% CI), P-value
	IHC1		H-Score2		QPCR3		IHC1		H-Score2		QPCR3
COX-1 / PTGS1
N cases / eventsa	47 / 15 vs 71 / 42		60 / 26 vs 58 / 31		15 / 12 vs 17 / 13		77 / 43 vs 113 / 77		95 / 57 vs 95 / 63		24 / 19 vs 25 / 18
Unadjusted	2.34 (1.30–4.24)	0.005	1.49 (0.88–2.50)	0.138	1.77 (0.79–3.98)	0.168	1.13 (0.78–1.65)	0.515	1.09 (0.76–1.56)	0.647	1.17 (0.61–2.23)	0.641
Adjustedb	1.58 (0.85–2.94)	0.148	1.44 (0.85–2.43)	0.180	4.12 (1.51–11.26)	0.006	0.79 (0.54–1.16)	0.227	0.97 (0.68–1.40)	0.882	2.02 (0.96–4.22)	0.063
Adjustedc	1.55 (0.81–2.98)	0.187	1.30 (0.75–2.34)	0.356	6.37 (1.84–22.01)	0.003	0.87 (0.59–1.30)	0.495	1.14 (0.78–1.65)	0.504	2.26 (1.04–4.91)	0.039
COX-2 / PTGS2
N cases / events	50 / 33 vs 68 / 24		46 / 29 vs 72 / 28		10 / 10 vs 14 / 9		103 / 80 vs 87 / 40		95 / 72 vs 95 / 48		18 / 16 vs 18 / 11
Unadjusted	0.51 (0.30–0.87)	0.013	0.61 (0.36–1.02)	0.061	0.51 (0.20–1.29)	0.154	0.52 (0.36–0.77)	< 0.001	0.57 (0.39–0.82)	0.002	0.59 (0.27–1.27)	0.173
Adjustedb	1.53 (0.85–2.76)	0.160	1.93 (1.08–3.46)	0.028	0.86 (0.30–2.45)	0.772	0.85 (0.57–1.27)	0.420	0.89 (0.61–1.31)	0.559	0.77 (0.35–1.71)	0.519
Adjustedc	1.54 (0.84–2.80)	0.161	1.92 (1.06–3.49)	0.033	0.87 (0.31–2.47)	0.798	1.05 (0.69–1.59)	0.818	1.05 (0.71–1.56)	0.802	1.40 (0.56–3.51)	0.477

¹COX protein measured by immunohistochemistry: moderate & strong vs weak

²COX protein measured by H-Score: dichotomized at median

³COX gene expression measured by quantitative real-time PCR: dichotomized at median

^aN cases / N events, reference vs high COX

^bAdjusted for age at diagnosis (continuous), stage (early, late), and tumor type (I, II)

^cAdditionally adjusted for debulking (optimal, suboptimal, missing) and platinum sensitivity (sensitive, resistant, missing) Bold values denote signficant associations; column percentages may not sum to 100% due to rounding error