. 2018 Feb 27;11:17. doi: 10.1186/s13048-018-0389-9

Table 4.

Associations between COX H-score and ovarian cancer survival by tumor type, the Vanderbilt TROC

	Disease-free survival			Overall survival
	HR (95% CI), P-value		P-interaction	HR (95% CI), P-value		P-interaction
COX-1 / PTGS1
Among Type I Cases (N = 65)
N cases / events^a	28 / 3 vs 21 / 5			39 / 14 vs 26 / 8
Unadjusted	2.20 (0.52–9.20)	0.282	0.537	0.71 (0.29–1.70)	0.435	0.210
Adjusted^b	2.88 (0.55–15.04)	0.209	0.537	0.56 (0.23–1.38)	0.210	0.210
Among Type II Cases (N = 125)
N cases / events^a	32 / 23 vs 37 / 26			56 / 43 vs 69 / 55
Unadjusted	1.32 (0.75–2.31)	0.339		1.10 (0.74–1.64)	0.636
Adjusted^b	1.34 (0.76–2.37)	0.313		1.07 (0.72–1.60)	0.740
COX-2 / PTGS2
Among Type I Cases (N = 65)
N cases / events^a	10 / 2 vs 39 / 6			19 / 11 vs 46 / 11
Unadjusted	0.90 (0.18–4.52)	0.899	0.181	0.38 (0.16–0.88)	0.023	0.051
Adjusted^b	0.51 (0.08–3.40)	0.490	0.181	0.49 (0.20–1.15)	0.102	0.051
Among Type II Cases (N = 125)
N cases / events^a	36 / 27 vs 33 / 22			76 / 61 vs 49 / 37
Unadjusted	1.07 (0.60–1.88)	0.829		0.84 (0.56–1.27)	0.413
Adjusted^b	1.93 (1.06–3.53)	0.033		1.08 (0.71–1.63)	0.723

^aN cases / N events, reference vs high COX, measured by H-score, dichotomized at the median

^bAdjusted for age at diagnosis (continuous) and stage (early, late) Bold values denote signficant associations; column percentages may not sum to 100% due to rounding error