TABLE 1.
Tx group | Animal no. 1 | Animal no. 2 | Animal no. 3 | Animal no. 4 | Animal no. 5 | Animal no. 6 | Animal no. 7 | Animal no. 8 |
---|---|---|---|---|---|---|---|---|
Control | PD | PD | PD | PD | PD | PD | PD | PD |
5 mg/kg KU363 | PR | CR | PR | PR | PR | PR | SD | SD |
25 mg/kg KU363 | CR | CR | PR | SD | PR | CR | PR | PR |
17-AAG | PR | PR | PD | PR | PR | SD | PR | SD |
Cisplatin | PR | PR | CR | CR | CR | CR | CR | CR |
Percentages are obtained by comparison of final tumor volume to tumor volume at time of first treatment
CR complete response, PR partial response (>30% reduction in tumor volume), SD stable disease (<30% reduction in tumor volume or <30% growth in tumor volume), PD progressive disease (>30% growth in tumor volume)