Fig 3. Ivermectin metabolized affects Plasmodium vivax development in Anopheles aquasalis and Anopheles darlingi.

An. aquasalis (A,C,E) and An. darlingi (B,D,F) mosquitoes were fed P. vivax with mIVM collected at various time points (0 and 4 hours; 1, 5, 10 and 14 days). (A) and (B) Proportion of P. vivax infected mosquitoes are presented as mean and standard deviation. (C) and (D) The intensity of infection is presented as the number of oocysts per a single midgut (black dots) and the black lines represent the median and standard deviation. (E) and (F) The mosquito mortality rate is presented as mean and standard deviation. Data from 5 independent experiments are presented. Asterisks (*) represent significant difference (P < 0.05) in relation to the control.