Fig 6. Plasmatic ivermectin and malaria drugs have a direct effect on Plasmodium vivax infection in Anopheles aquasalis.

An. aquasalis female mosquitos were fed with unprocessed blood samples from P. vivax patients at time 0 (control) or 4 hours after different treatment regimens intake or with erythrocytes from P. vivax patients’ blood samples (before treatment) reconstituted to a hematocrit of 40% with the respective plasma after 4 hours of different treatment regimens intake. (A) The proportion of P. vivax infected mosquitos are presented as mean and standard deviation. Black bars represent the unprocessed blood and the grey bars represent the reconstitute samples. (B) The intensity of infection is presented as the number of oocysts per a single mosquito midgut (dots), black dots represent the unprocessed blood and the grey dots represent the reconstituted blood samples, and the black lines represent the median and standard error blood. Asterisks (*) represent significant difference (P < 0.05) in relation to the control.