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. 2018 Feb 14;14(2):e1006861. doi: 10.1371/journal.ppat.1006861

Table 1. T-cell subsets and proviral load in AC, HAM and ATL.

Patient group Parameter CD3 CD4 CD8 PVL (copies per 100 PBMCS)
Absolute count (10^6/uL) Relative count (% lymphocytes) Absolute count (10^6/uL) Relative count (% lymphocytes) Absolute count (10^6/uL) Relative count (% lymphocytes)
AC (n = 17) Minimum 881 61.4 539 30 194 12 <0.1
25% Percentile 1139 67 860 45 289 15 0.7
Median 1454 73 989 53 385 19 2.8
75% Percentile 1852 79 1260 58 518 27 18.9
Maximum 2970 87 1563 66 1470 42 27.9
Mean 1458 73 1049 51 461 22 9.4
Std. Deviation 631 8 301 9 360 10 10.4
Std. Error 158 2 78 2 90 2 2.5
HAM (n = 28) Minimum 723 59 264 22 232 17 0.4
25% Percentile 1112 74 678 44 342 22 4.4
Median 1347 79 864 50 508 25 6.9
75% Percentile 2057 84 1301 55 855 36 12.6
Maximum 3768 95 2368 60 1495 73 28.8
Mean 1644 78 1012 48 633 30 9.0
Std. Deviation 789 9 522 10 371 13 7.2
Std. Error 147 2 97 2 69 2 1.3
ATL (n = 28) Minimum 574 38 334 22 160 1 2.0
25% Percentile 2345 81 1454 58 287 3 20.3
Median 6494 93 5499 83 366 8 29.8
75% Percentile 11868 95 10600 91 531 16 64.6
Maximum 91000 99 11612 94 1252 31 276.2
Mean 14534 85 5695 73 446 10 54.3
Std. Deviation 24674 16 4343 22 263 9 59.9
Std. Error 5384 4 1024 5 62 2 11.8
Significance of difference? AC vs HAM Ns Ns ns ns ns ns ns
AC vs ATL *** *** * *** ns * ***
HAM vs ATL *** *** *** *** ns *** ***

* denotes p<0.05,

*** denotes p<0.001, ns denotes not significant

AC denotes asymptomatic carriers, HAM denotes HTLV-1-associated myelopathy, ATL denotes adult T-cell leukaemia/lymphoma