Table 1. T-cell subsets and proviral load in AC, HAM and ATL.
Patient group | Parameter | CD3 | CD4 | CD8 | PVL (copies per 100 PBMCS) | |||
---|---|---|---|---|---|---|---|---|
Absolute count (10^6/uL) | Relative count (% lymphocytes) | Absolute count (10^6/uL) | Relative count (% lymphocytes) | Absolute count (10^6/uL) | Relative count (% lymphocytes) | |||
AC (n = 17) | Minimum | 881 | 61.4 | 539 | 30 | 194 | 12 | <0.1 |
25% Percentile | 1139 | 67 | 860 | 45 | 289 | 15 | 0.7 | |
Median | 1454 | 73 | 989 | 53 | 385 | 19 | 2.8 | |
75% Percentile | 1852 | 79 | 1260 | 58 | 518 | 27 | 18.9 | |
Maximum | 2970 | 87 | 1563 | 66 | 1470 | 42 | 27.9 | |
Mean | 1458 | 73 | 1049 | 51 | 461 | 22 | 9.4 | |
Std. Deviation | 631 | 8 | 301 | 9 | 360 | 10 | 10.4 | |
Std. Error | 158 | 2 | 78 | 2 | 90 | 2 | 2.5 | |
HAM (n = 28) | Minimum | 723 | 59 | 264 | 22 | 232 | 17 | 0.4 |
25% Percentile | 1112 | 74 | 678 | 44 | 342 | 22 | 4.4 | |
Median | 1347 | 79 | 864 | 50 | 508 | 25 | 6.9 | |
75% Percentile | 2057 | 84 | 1301 | 55 | 855 | 36 | 12.6 | |
Maximum | 3768 | 95 | 2368 | 60 | 1495 | 73 | 28.8 | |
Mean | 1644 | 78 | 1012 | 48 | 633 | 30 | 9.0 | |
Std. Deviation | 789 | 9 | 522 | 10 | 371 | 13 | 7.2 | |
Std. Error | 147 | 2 | 97 | 2 | 69 | 2 | 1.3 | |
ATL (n = 28) | Minimum | 574 | 38 | 334 | 22 | 160 | 1 | 2.0 |
25% Percentile | 2345 | 81 | 1454 | 58 | 287 | 3 | 20.3 | |
Median | 6494 | 93 | 5499 | 83 | 366 | 8 | 29.8 | |
75% Percentile | 11868 | 95 | 10600 | 91 | 531 | 16 | 64.6 | |
Maximum | 91000 | 99 | 11612 | 94 | 1252 | 31 | 276.2 | |
Mean | 14534 | 85 | 5695 | 73 | 446 | 10 | 54.3 | |
Std. Deviation | 24674 | 16 | 4343 | 22 | 263 | 9 | 59.9 | |
Std. Error | 5384 | 4 | 1024 | 5 | 62 | 2 | 11.8 | |
Significance of difference? | AC vs HAM | Ns | Ns | ns | ns | ns | ns | ns |
AC vs ATL | *** | *** | * | *** | ns | * | *** | |
HAM vs ATL | *** | *** | *** | *** | ns | *** | *** |
* denotes p<0.05,
*** denotes p<0.001, ns denotes not significant
AC denotes asymptomatic carriers, HAM denotes HTLV-1-associated myelopathy, ATL denotes adult T-cell leukaemia/lymphoma