Table 3. TCR clonality within ‘ATL-like’ cells in patient with non-malignant HTLV-1 infection and ATL.

Patient group	CODE	Total reads (x10^6)	TCR-Beta						TCR-alpha
			Reads aligned to CDR3	Read aligned to CDR3 per 10^4 total reads	Number of clones	clonal Fraction of largest clone	clonal Fraction of second largest clone	clonal Fraction of two largest clone	Reads aligned to CDR4	Read aligned to CDR3 per 10^4 total reads	Number of clones	clonal Fraction of largest clone	clonal Fraction of second largest clone	clonal Fraction of two largest clone
ATL	ATL12	52	4726	9	16	0.99	0.00	1.00	1533	3	7	0.88	0.11	0.99
	ATL22	72	23775	33	7	1.00	0.00	1.00	2430	3	3	0.99	0.00	0.99
	ATL197	79	8111	10	10	1.00	0.00	1.00	3131	4	9	0.98	0.01	0.99
	LFA	73	9175	13	33	0.55	0.43	0.98	4663	6	19	0.93	0.06	0.99
	LFV	70	3453	5	3	1.00	0.00	1.00	2036	3	4	0.68	0.32	1.00
	LGL	130	14027	11	38	0.95	0.03	0.98	7073	5	37	0.85	0.10	0.95
	LGV	66	35	0	26	0.09	0.09	0.17	2683	4	13	0.95	0.05	1.00
	LHN	70	2399	3	48	0.95	0.01	0.96	1190	2	33	0.68	0.28	0.96
	Median	71	6419	10	21	0.97	0.01	1.00	2557	4	11	0.91	0.08	0.99
non-malignant	HES	50	2322	5	322	0.04	0.03	0.07	907	2	161	0.02	0.02	0.04
	HHL	78	2532	3	290	0.07	0.06	0.13	1779	2	183	0.23	0.03	0.26
	HKQ	9	380	4	72	0.04	0.03	0.07	185	2	39	0.07	0.04	0.11
	HKU	57	2385	4	181	0.40	0.32	0.73	1062	2	112	0.34	0.13	0.47
	TBG	86	5529	6	1130	0.04	0.03	0.06	2221	3	667	0.05	0.03	0.08
	TCD	117	8276	7	2531	0.01	0.01	0.02	4506	4	1750	0.01	0.01	0.02
	TCX	155	11643	8	1385	0.09	0.03	0.12	5702	4	1157	0.06	0.03	0.09
	TDU	91	4123	5	359	0.02	0.02	0.03	2494	3	248	0.02	0.02	0.04
	Median	82	3328	5	340.5	0.04	0.03	0.07	2000	2	216	0.06	0.03	0.09
significant of difference between ATL and non-malignant	p value	0.72	0.38	0.23	0.0002	0.0016	0.1971	0.0012	0.33	0.11	0.0002	0.0009	0.21	0.0009
	Comment	not significant	not significant	not significant	***	**	not significant	**	not significant	not significant	***	***	not significant	***