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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Acta Neuropathol. 2017 Nov 18;135(1):13–32. doi: 10.1007/s00401-017-1788-5

Figure 1. Schema for role of proaggregant nuclear factors in α-synuclein aggregation.

Figure 1

Filamentous αS aggregates can be rapidly formed in apoptotic neurons by interaction between αS and nuclear proaggregant factors associated with disruption of nuclear envelope. Such aggregates can be released from apoptotic bodies and taken up by surrounding healthy neurons as a potential seed for subsequent propagation.