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. Author manuscript; available in PMC: 2018 Oct 24.
Published in final edited form as: Cell Rep. 2017 Oct 24;21(4):1077–1088. doi: 10.1016/j.celrep.2017.10.001

Figure 1. Schematic Overview of Our Approach.

Figure 1

We characterized tissue-specific gene regulation starting with GTEx gene expression data; the relative sample size of each of the 38 tissues in the expression data is shown in the color bar. We then used PANDA to integrate this information with protein-protein interaction (PPI) and transcription factor (TF) target information, producing 38 inferred gene regulatory networks, one for each tissue. We identified tissue-specific genes, transcription factors, and regulatory network edges, and we analyzed their properties within and across these networks.