Table 2.
Relationships between patient and clinical characteristics of women with breast cancer and mammographic density measurements (unadjusted and adjusted analysis).
| Clinical characteristic | n | (%) | Percent density (%) | Absolute dense area | Nondense area | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Unadjusted | Adjusted∗ | Unadjusted | Adjusted∗ | Unadjusted | Adjusted∗ | |||||||||||||||
| Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | |||||||||
| Age | ||||||||||||||||||||
| <50 years | 48 | 39 | 31.9 | 28.6 | 35.2 | 31.8 | 28.4 | 35.2 | 106.2 | 91.5 | 120.9 | 110.1 | 95.0 | 125.3 | 223.8 | 189.3 | 258.4 | 232.5 | 200.3 | 264.8 |
| ≥50 years | 75 | 61 | 19.9 | 17.8 | 22.0 | 19.8 | 17.7 | 21.9 | 70.7 | 61.1 | 80.2 | 72.1 | 62.4 | 81.7 | 301.6 | 269.5 | 333.7 | 306.9 | 277.7 | 336.0 |
| P value | <0.01 | <0.01 | <0.01 | <0.01 | 0.03 | 0.02 | ||||||||||||||
| Menopausal status | ||||||||||||||||||||
| Pre | 42 | 34 | 30.7 | 27.1 | 34.2 | 24.0 | 19.9 | 28.0 | 96.2 | 80.9 | 111.5 | 69.1 | 52.8 | 85.4 | 214.1 | 178.2 | 250.1 | 228.8 | 184.8 | 272.8 |
| Post | 81 | 66 | 21.2 | 19.0 | 23.3 | 24.1 | 21.6 | 26.7 | 77.5 | 67.6 | 87.4 | 94.7 | 82.7 | 106.7 | 301.4 | 270.6 | 332.1 | 303.1 | 271.3 | 334.9 |
| P value | <0.01 | 0.96 | 0.15 | 0.13 | 0.01 | 0.10 | ||||||||||||||
| BMI category | ||||||||||||||||||||
| Lean | 18 | 15 | 27.0 | 21.7 | 32.2 | 26.2 | 21.4 | 31.0 | 50.8 | 34.3 | 67.3 | 49.1 | 33.3 | 64.8 | 133.8 | 95.1 | 172.5 | 137.0 | 98.6 | 175.5 |
| Overweight | 54 | 44 | 25.4 | 22.5 | 28.4 | 24.9 | 22.2 | 27.6 | 86.1 | 73.6 | 98.6 | 84.5 | 72.5 | 96.5 | 261.9 | 230.4 | 293.3 | 265.1 | 234.1 | 296.2 |
| Obese | 43 | 35 | 21.3 | 18.3 | 24.3 | 22.2 | 19.3 | 25.1 | 102.9 | 87.6 | 118.2 | 106.1 | 91.0 | 121.2 | 376.0 | 333.8 | 418.2 | 368.8 | 327.6 | 409.9 |
| P value for trend | 0.29 | 0.52 | 0.01 | <0.01 | <0.01 | <0.01 | ||||||||||||||
| Diagnosis | ||||||||||||||||||||
| Invasive ductal | 105 | 85 | 24.6 | 22.5 | 26.6 | 24.1 | 22.1 | 26.0 | 80.7 | 71.8 | 89.6 | 82.8 | 74.3 | 91.4 | 256.7 | 231.5 | 281.9 | 268.0 | 245.2 | 290.8 |
| Other | 18 | 15 | 22.6 | 17.7 | 27.4 | 23.9 | 18.9 | 28.9 | 101.8 | 77.7 | 125.9 | 106.2 | 81.2 | 131.2 | 353.4 | 282.1 | 424.7 | 342.3 | 275.8 | 408.8 |
| P value | 0.59 | 0.94 | 0.25 | 0.21 | 0.07 | 0.14 | ||||||||||||||
| Tumor size | ||||||||||||||||||||
| <3 cm | 53 | 43 | 22.7 | 19.9 | 25.6 | 22.1 | 19.4 | 24.7 | 72.5 | 60.8 | 84.1 | 74.4 | 63.3 | 85.5 | 254.5 | 218.6 | 290.4 | 271.3 | 238.5 | 303.1 |
| ≥3 cm | 58 | 47 | 24.8 | 22.0 | 27.7 | 24.9 | 22.2 | 27.7 | 91.5 | 79.0 | 104.1 | 93.2 | 80.9 | 105.5 | 289.9 | 253.3 | 326.5 | 283.6 | 255.6 | 321.6 |
| P value | 0.47 | 0.30 | 0.13 | 0.12 | 0.34 | 0.60 | ||||||||||||||
| Tumor grade | ||||||||||||||||||||
| Grade 1 | 14 | 11 | 31.4 | 25.0 | 37.9 | 30.5 | 24.6 | 36.4 | 107.3 | 78.9 | 135.7 | 118.7 | 91.1 | 146.4 | 253.2 | 184.8 | 321.5 | 295.5 | 230.5 | 360.4 |
| Grade 2 | 57 | 46 | 22.8 | 20.1 | 25.6 | 22.9 | 20.3 | 25.5 | 82.0 | 69.7 | 94.3 | 88.2 | 76.1 | 100.3 | 280.3 | 244.5 | 316.1 | 294.4 | 261.5 | 327.4 |
| Grade 3 | 49 | 40 | 24.8 | 21.7 | 27.8 | 24.1 | 21.3 | 27.0 | 78.8 | 65.8 | 91.9 | 74.2 | 62.2 | 86.1 | 247.5 | 211.2 | 283.8 | 242.0 | 209.9 | 274.2 |
| P value for trend | 0.21 | 0.25 | 0.43 | 0.10 | 0.65 | 0.26 | ||||||||||||||
| BMI: body mass index | ||||||||||||||||||||
| Nodal status | ||||||||||||||||||||
| Negative | 49 | 40 | 24.8 | 21.6 | 27.9 | 24.1 | 21.1 | 27.0 | 92.1 | 78.2 | 106.0 | 91.6 | 78.3 | 104.9 | 297.9 | 257.8 | 337.9 | 298.4 | 263.1 | 333.8 |
| Positive | 60 | 49 | 22.9 | 20.2 | 25.6 | 22.9 | 20.3 | 25.4 | 76.1 | 64.7 | 87.5 | 79.4 | 68.5 | 90.3 | 257.2 | 223.5 | 290.8 | 270.3 | 240.7 | 299.8 |
| P value | 0.53 | 0.67 | 0.22 | 0.33 | 0.28 | 0.40 | ||||||||||||||
∗Adjusted for age and BMI. BMI: body mass index.