Table 3.
Relationship between MD and tumor subtype (overall and stratified by menopausal status) among women included in this study.
| Clinical characteristic | n | (%) | Percent density (%) | Absolute dense area | Nondense area | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Unadjusted | Adjusted∗∗ | Unadjusted | Adjusted∗∗ | Unadjusted | Adjusted∗∗ | |||||||||||||||
| Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | |||||||||
| All women | ||||||||||||||||||||
| ER status | ||||||||||||||||||||
| Negative | 33 | 27 | 20.0 | 16.7 | 23.3 | 19.3 | 16.2 | 22.4 | 61.2 | 47.7 | 74.7 | 63.2 | 49.9 | 76.6 | 280.3 | 232.7 | 327.8 | 286.0 | 242.7 | 329.3 |
| Positive | 90 | 73 | 25.9 | 23.7 | 28.2 | 25.8 | 23.7 | 28.0 | 92.8 | 82.7 | 102.9 | 94.4 | 84.8 | 104.1 | 266.1 | 238.0 | 294.2 | 274.1 | 249.0 | 299.2 |
| P value | 0.04 | 0.02 | 0.01 | 0.01 | 0.73 | 0.76 | ||||||||||||||
| Premenopausal women | ||||||||||||||||||||
| ER status | ||||||||||||||||||||
| Negative | 9 | 21 | 24.5 | 17.5 | 31.6 | 25.0 | 16.7 | 33.4 | 73.6 | 44.1 | 103.1 | 63.3 | 31.0 | 95.6 | 249.2 | 178.4 | 320.0 | 216.4 | 140.7 | 292.1 |
| Positive | 33 | 79 | 32.5 | 28.3 | 36.8 | 32.2 | 27.7 | 36.7 | 103.4 | 85.0 | 121.8 | 104.8 | 85.0 | 124.6 | 205.4 | 171.7 | 239.1 | 209.7 | 174.5 | 244.8 |
| P value | 0.19 | 0.31 | 0.25 | 0.16 | 0.45 | 0.95 | ||||||||||||||
| Postmenopausal women | ||||||||||||||||||||
| ER status | ||||||||||||||||||||
| Negative | 24 | 30 | 18.4 | 14.9 | 22.0 | 17.0 | 13.8 | 20.1 | 57.3 | 42.4 | 72.3 | 64.4 | 50.5 | 78.4 | 293.6 | 233.6 | 353.5 | 336.8 | 283.5 | 390.2 |
| Positive | 57 | 70 | 22.5 | 20.0 | 25.0 | 22.9 | 20.6 | 25.3 | 87.2 | 75.1 | 99.2 | 88.6 | 78.0 | 99.3 | 305.4 | 265.7 | 345.2 | 304.5 | 271.5 | 337.5 |
| P value | 0.20 | 0.05 | 0.04 | 0.07 | 0.81 | 0.48 | ||||||||||||||
| All women | ||||||||||||||||||||
| PR status | ||||||||||||||||||||
| Negative | 40 | 33 | 22.0 | 18.9 | 25.2 | 22.4 | 19.2 | 25.5 | 65.0 | 52.3 | 77.7 | 71.4 | 58.2 | 84.5 | 250.9 | 210.1 | 291.7 | 259.2 | 221.6 | 296.9 |
| Positive | 83 | 67 | 25.4 | 23.0 | 27.7 | 24.8 | 22.6 | 27.1 | 93.5 | 82.9 | 104.1 | 92.7 | 82.6 | 102.7 | 279.3 | 249.4 | 309.2 | 285.6 | 259.0 | 312.2 |
| P value | 0.25 | 0.38 | 0.02 | 0.08 | 0.43 | 0.43 | ||||||||||||||
| Premenopausal women | ||||||||||||||||||||
| PR status | ||||||||||||||||||||
| Negative | 11 | 26 | 26.0 | 19.4 | 32.6 | 28.1 | 19.9 | 36.3 | 78.4 | 50.7 | 106.1 | 78.1 | 44.7 | 111.5 | 241.4 | 178.2 | 304.6 | 217.0 | 148.1 | 285.9 |
| Positive | 31 | 74 | 32.5 | 28.1 | 36.9 | 31.7 | 27.0 | 36.4 | 103.5 | 84.4 | 122.5 | 102.5 | 81.6 | 123.4 | 205.3 | 170.5 | 240.1 | 209.1 | 172.4 | 245.8 |
| P value | 0.27 | 0.59 | 0.31 | 0.40 | 0.50 | 0.92 | ||||||||||||||
| Postmenopausal women | ||||||||||||||||||||
| PR status | ||||||||||||||||||||
| Negative | 29 | 36 | 20.7 | 17.3 | 24.1 | 19.5 | 16.3 | 22.7 | 60.6 | 46.6 | 74.7 | 68.5 | 55.2 | 81.9 | 255.4 | 205.3 | 305.6 | 296.9 | 250.8 | 343.0 |
| Positive | 52 | 64 | 21.6 | 18.9 | 24.2 | 21.9 | 19.5 | 24.4 | 88.1 | 75.4 | 100.8 | 88.2 | 77.1 | 99.3 | 329.5 | 286.9 | 372.1 | 323.4 | 288.1 | 358.7 |
| P value | 0.77 | 0.41 | 0.05 | 0.12 | 0.13 | 0.53 | ||||||||||||||
| All women | ||||||||||||||||||||
| TNBC status | ||||||||||||||||||||
| No | 95 | 77 | 25.8 | 23.5 | 28.0 | 26.1 | 23.9 | 28.2 | 92.9 | 83.1 | 102.7 | 96.6 | 87.4 | 105.7 | 271.3 | 244.6 | 298.1 | 279.2 | 255.5 | 302.8 |
| Yes | 21 | 17 | 20.1 | 15.9 | 24.3 | 17.4 | 13.6 | 21.1 | 58.7 | 42.2 | 75.2 | 56.3 | 41.1 | 71.4 | 266.5 | 210.2 | 322.8 | 287.2 | 234.9 | 339.4 |
| P value | 0.11 | 0.01 | 0.02 | <0.01 | 0.89 | 0.87 | ||||||||||||||
| Premenopausal women | ||||||||||||||||||||
| TNBC status | ||||||||||||||||||||
| No | 33 | 85 | 33.1 | 28.7 | 37.4 | 33.1 | 28.6 | 37.6 | 111.6 | 93.9 | 129.3 | 115.7 | 97.9 | 133.5 | 218.9 | 187.8 | 250.0 | 225.0 | 193.6 | 256.4 |
| Yes | 6 | 15 | 22.0 | 13.7 | 30.2 | 19.0 | 10.4 | 27.5 | 54.1 | 25.7 | 82.5 | 37.3 | 12.5 | 62.1 | 222.9 | 149.7 | 296.1 | 216.7 | 139.3 | 294.1 |
| P value | 0.12 | 0.07 | 0.04 | 0.01 | 0.98 | 0.85 | ||||||||||||||
| Postmenopausal women | ||||||||||||||||||||
| TNBC status | ||||||||||||||||||||
| No | 62 | 81 | 22.3 | 19.8 | 24.7 | 22.9 | 20.6 | 25.2 | 83.8 | 72.2 | 95.4 | 87.6 | 77.2 | 98.0 | 301.9 | 264.2 | 339.7 | 306.7 | 274.4 | 339.1 |
| Yes | 15 | 19 | 19.5 | 14.9 | 24.1 | 16.4 | 12.4 | 20.4 | 61.4 | 41.4 | 81.4 | 64.0 | 45.8 | 82.2 | 286.7 | 212.1 | 361.3 | 331.9 | 262.9 | 400.9 |
| P value | 0.46 | 0.07 | 0.19 | 0.13 | 0.78 | 0.66 | ||||||||||||||
| All women | ||||||||||||||||||||
| HER2 status | ||||||||||||||||||||
| Negative | 94 | 76 | 24.2 | 22.0 | 26.4 | 23.8 | 21.7 | 25.8 | 83.1 | 73.6 | 92.6 | 86.4 | 77.4 | 95.5 | 270.2 | 243.3 | 297.1 | 284.8 | 260.8 | 308.8 |
| Positive | 22 | 18 | 26.9 | 22.1 | 31.7 | 27.4 | 22.8 | 32.1 | 99.5 | 78.1 | 121.0 | 99.3 | 78.9 | 119.7 | 271.4 | 215.9 | 327.0 | 262.0 | 213.6 | 310.5 |
| P value | 0.49 | 0.32 | 0.33 | 0.43 | 0.99 | 0.55 | ||||||||||||||
∗∗Adjusted for age and BMI and additionally adjusted for menopausal status in analyses that included all women. BMI: body mass index; ER: estrogen receptor; HER2: human epidermal growth factor receptor 2; PR: progesterone receptor; TNBC: triple negative breast cancer; CI: confidence intervals.