Table 2.

Suicide attempt severity associated methylation changes in HPA-axis coupled CpG sites.

Gene	Transcript	Illumina ID	logFC	t	P.Value	adj.P.Val	B
CRH	NM_000756	cg23409074	− 0.33	− 3.84	2.29E-04	1.65E-02	0.36
CRH	NM_000756	cg19035496	− 0.27	− 3.52	6.92E-04	4.98E-02	− 0.64
CRHBP	AK311052	cg13777717	0.16	2.49	1.45E-02	ns	− 3.35
CRHR1	EU012435	cg24063856	− 0.15	− 2.04	4.39E-02	ns	− 4.31
CRHR1	BC037967	cg12577105	0.12	1.91	5.90E-02	ns	− 4.55
NR3C1	HQ450644	cg08845721	− 0.12	− 1.90	6.12E-02	ns	− 4.57
CRH	NM_000756	cg08215831	− 0.15	− 1.86	6.69E-02	ns	− 4.65
CRHR2	EU012442	cg01972879	0.10	1.71	9.13E-02	ns	− 4.89
CRHR1	EU012435	cg11338426	0.07	1.54	1.28E-01	ns	− 5.14
CRHR2	EU012442	cg04923928	− 0.10	− 1.51	1.35E-01	ns	− 5.20

Analysis by multiple linear regression models of methylation M-values to a binary outcome variable of suicide attempt severity (high vs low), adjusting for gender, occurrence of completed suicide, alcohol dependence and occurrence of other (non-borderline) personality disorder. 72 individual HPA-axis associated CpG-sites were studied. p-Values were corrected for multiple testing using the bonferroni-method. Abbreviations: B, log-odds that the CpG-site is differentially methylated; logFC, log fold change; ns, not significant; p, p-value; t, moderated t-statistic.

Significant findings in bold.