Table 1.
Natural product biosynthetic domains and enzymes of Ca. E. serta TSWA1 compared with the two previously sequenced Entotheonella variants
| Domain type | Ca. E. serta TSWA1 | Ca. E. factor TSY1 | Ca. E. gemina TSY2 |
| NRPS | |||
| Adenylation | 46 | 44 | 11 |
| (Known compounds) | (11) | (26) | (0) |
| Condensation | 43 | 40 | 11 |
| Peptidyl-carrier protein | 45 | 50 | 11 |
| Thioesterase | 11 | 5 | 3 |
| Other NRPS domain | 6 | 8 | 5 |
| PKS | |||
| Ketosynthase | 34 | 25 | 5 |
| (Known compounds) | (22) | (16) | (0) |
| Acyltransferase | 17 | 14 | 6 |
| trans-AT docking | 19 | 12 | 0 |
| Ketoreductase | 21 | 19 | 4 |
| Dehydratase | 11 | 8 | 1 |
| Acyl-carrier protein | 33 | 21 | 3 |
| Thioesterase | 4 | 4 | 2 |
| Type III PKS system | 2 | 1 | 1 |
| Other PKS domain | 12 | 11 | 3 |
| RiPP | |||
| RiPP precursors | 0 | 4 | 5 |
| RiPP maturation enzymes | 1 | 6 | 7 |
| Terpene/Ectoine/Indolocarbazole | 3 | 3 | 1 |
| Total | 308 | 275 | 79 |
Adenylation and ketosynthase domains attributed to known compounds are shown in parentheses. For a more complete breakdown, see SI Appendix, Table S4.