Fig. 5.

RNA-editing regulated genes in LUAD are enriched in apoptosis and innate immune-related genes. Biocarta pathway enrichments of genes with 5 or more predicted regulatory RNA editing sites (A). Pathway diagram showing the genes that are enriched in the apoptosis (B) and innate immune-related pathways (C). Blue and red colored proteins indicate positive and negative regulation by ADAR-mediated RNA editing, respectively. The MAVS protein is colored in both blue and red because there are both positive and negative regulatory edits within its 3′ UTR.