Table 2. Treatment and parasitological data per study group.
| LD-SP/SP | LD-SP/PIP | LD-PIP/PIP | LD-PIP/SP | ||
|---|---|---|---|---|---|
| Time to T1 (days) | Median (range) | 13 (9.3–12.8) | 10.8 (0.8–11.8) |
10.3 (10.3–12.3) |
12.8 (12.3–14.3) |
| Time between T1-T2 (days) | Median (range) | 9.1 (7.7–11.7) |
10 (9.2–10.2) | 4.7 (2–10.7) | 2.5 (1.5–5.0) |
| Area under the curve (AUC)* | Median (range) | ||||
| Asexual | 6490 (1120–16337) | 13280 (2773–43777) | 14347 (5408–24898) | 12747 (4572–82973) | |
| Sexual | 280 (27–3640) | 271 (64–848) | 784 (316–1274) | 6624 (1515–10244) | |
| Peak parasite density (Pf/mL) | Median (range) | 6467 (1050–20261) | 16376 (2590–50210) | 11603 (2408–21565) | 8491 (3976–63113) |
| Peak gametocyte density (gct/mL) | Median (range) | 38 (11–368) | 30 (13–101) | 83 (46–99) | 627 (199–1285) |
| Day of gametocyte detection after infection (days) | Mean (SD) | 18.3 (1.0) | 18.5 (1.0) | 17.3 (1.5) | 19.4 (1.3) |
| Time to gametocyte detection relative to first asexual parasites† (days) | Mean (SD) | 10.5 (1.3) | 11.5 (1.0) | 10.1 (1.3) | 10.1 (1.2) |
| Proportion of days gametocyte positive (%)‡ | Mean (SD) | 27.4 (6.7) | 35.9 (7.6) | 51.4 (7.9) | 48.3 (8.1) |
| Duration gametocytemia§ (days) | Median (range) | 7.5 (1–24) | 6 (2–14) | 17 (12–25) | 24.5 (17–25) |
*The area under the curve (AUC) represents the total parasite exposure over time (asexual- or sexual parasite load).
†Time to gametocyte detection is calculated as the day of the detection of gametocytes (≥5 gct/mL) minus the day of first peak asexual parsitaemia.
‡The proportion of gametocyte positive days is calculated as all days with ≥5 gct/mL by Pfs25-qRT-PCR divided by all days where Pfs25 qRT-PCR was performed.
§Maximum number of consecutive days of Pfs25 qRT-PCR measured gametocytemia ≥5 gct/mL.