Table 1. Published studies reporting conservative treatment among breast cancer patients previously treated for HL.

Study	Re-irradiation technique	Dose in Gy	Median follow-up in mo (range)	Toxicity events	Locoregional recurrence rate (%)	Cosmetic result
Wolden et al. [14] n = 2	WBRT with tangential fields	45.6, 46	72, 168a	Severe soft tissue necrosis	0	NA
Aref et al. [22] n = 2	WBRT	46, 48	27, 32a	No	0	Good to excellent
Deutsch et al. [18] n = 11	WBRT	50–51	46 (1–74)	No	0	Good to excellent
Cutuli et al. [23] n = 32	WBRT	NA	40 (10–192)	No	12.5	NA
Intra et al. [17] n = 6	ELIOT	17, 21	30.8b (17–53)	No	8	Very good
Sana et al. [24] n = 33	EBRT, ELIOT	NA	41 (1–101)	NA	<5d	NA
El-Din et al. [19] n = 1	3D conformal PBI	50	27a	Moderate erythema	0	Excellent
Chadha et al. [25] n = 5	PBB	45	(5–67)	No	0	Excellent
Nguyen et al. [21] n = 2	WBRT	45, 50	43c (6–127)	G1c	0	NA
Intra et al.c [26] n = 35	ELIOT	17, 18, 21	52 (6–132)	G1, G2 subcutaneous tissue	9	Very good
Cutuli et al. [27] n = 56	WBRT	NA	50	No	13.7	NA
Haberer et al. [20] n = 30	WBRT	39.6–52.2	84 (4.8-384)	NA	7d	NA
Chadha et al. [28] n = 8	PBB	45e, f	73f	G1 skin pigmentation + G3 fibrosisf	1d	Excellent
Terenziani et al. [29] n = 29	NA	28–60	99	No	NA	NA
Burt et al. [30] n = 46	NA	NA	57 (0–299)	NA	NA	NA

^aFollow-up in months;

^bAverage follow-up;

^cData for HL+NHL;

^dNumber of locoregional recurrences;

^eMedian dose;

^fData for patients with prior HL+ prior history of breast cancer.

Abbreviations: EBRT: External beam radiation therapy; ELIOT: Intraoperative radiotherapy with electrons; G: Grade; NA: Not available; PBB: Partial breast brachytherapy; PBI: Partial breast irradiation; WBRT: Whole breast radiotherapy.