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. Author manuscript; available in PMC: 2019 Jun 20.
Published in final edited form as: Annu Rev Biochem. 2017 Aug 25;87:783–807. doi: 10.1146/annurev-biochem-062917-011852

Figure 3.

Figure 3

The domains of Scap. Luminal Loop 1 (purple) binds cholesterol and Loop 7, and it contains one N-linked glycosylation site. The sterol-sensing domain (blue), which is comprised of transmembrane helices 2–6, binds Insigs. Cytoplasmic Loop 6 (red), which contains the hexapeptide MELADL, binds COPII proteins. Loop 7 (orange) binds Loop 1 and contains two N-linked sites. The COOH-terminal 523 amino acids (green box) contain at least five WD-repeat sequences that bind the COOH-terminal domain of SREBPs. Abbreviations: COPII, coat protein II; MELADL sequence, methionine-glutamate-leucine-alanine-aspartate-leucine; SREBPs, sterol regulatory element-binding proteins.