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. Author manuscript; available in PMC: 2019 Jun 20.
Published in final edited form as: Annu Rev Biochem. 2017 Aug 25;87:783–807. doi: 10.1146/annurev-biochem-062917-011852

Table 1.

Membrane proteins that contain sterol-sensing domainsa

Protein Function Reference(s)
Scap Cholesterol-regulated transporter of SREBPs from the endoplasmic reticulum to the Golgi 1
HMG CoA reductase Biosynthesis of cholesterol 1
7-DHCR Biosynthesis of cholesterol 65
NPC1 Intracellular cholesterol transport within lysosomes 33,66
NPC1L1 Intestinal cholesterol absorption 67
Patched Hedgehog signaling pathway 33,66
Dispatched Hedgehog signaling pathway 68
TRC8 Ubiquitin E3 ligase involved in degradation of HMG CoA reductase and heme oxygenase 33,69,70
a

For a review of the sterol-sensing domain, see Reference 71.

Abbreviations: 7-DHCR, 7-dehydrocholesterol reductase; HMG CoA reductase, 3-hydro-3-methylglutaryl coenzyme A reductase; NPC1, Niemann-Pick C1; NPC1L1, Niemann-Pick C1-like 1; SREBPs, sterol regulatory element-binding proteins; TRC8, translocation in renal cancer from chromosome 8.