. Author manuscript; available in PMC: 2019 Apr 1.

Published in final edited form as: Magn Reson Imaging. 2017 Nov 15;47:16–24. doi: 10.1016/j.mri.2017.11.002

Table 1.

Results of DCE MRI Analyses

Model	Parameter	ROI			Pixel

		Mean	IQR	wSCV	Mean	IQR	wSCV
Quantitative Parameters (Reference Region)

LRRM	R^Ktrans	2.57	1.86–3.23	0.41	2.40	1.67–3.16	0.40
LRRM	k_ep,TOI	0.11	0.01–0.73	0.74	0.03	0.0–0.04	0.68
NRRM	R^Ktrans	1.52	1.02–2.61	0.97	1.99	1.13–2.97	0.92
NRRM	k_ep,TOI	1.03	0.62–1.47	0.91	1.33	0.81–1.55	0.73
NRRM*	R^Ktrans	1.24	0.73–1.68	0.74	1.99	1.13–2.97	0.63
NRRM*	k_ep,TOI	0.45	0.12–0.71	0.61	0.30	0.07–0.43	0.53

Quantitative Parameters (Tofts Model)

LTM	K^trans	0.25	0.03–0.34	0.43	0.22	0.09–0.24	0.66
LTM	k_ep,TOI	0.85	0.64–1.10	0.37	0.90	0.73–1.05	0.21
NTM	K^trans	0.16	0.09–0.24	0.57	0.18	0.17–0.21	0.20
NTM	k_ep,TOI	7.64	6.89–8.04	0.19	8.20	8.67–9.48	0.45
NTM*	K^trans	0.08	0.05–0.11	0.43	0.05	0.04–0.05	0.27
NTM*	k_ep,TOI	1.87	1.04–2.32	0.26	2.21	1.59–2.83	0.29

Semi-Quantitative Parameters

	MER	5.93	4.56 – 8.22	0.44	7.46	6.22 – 8.81	0.25
	TTP	3.79	3.20 – 4.05	0.15	3.09	2.99 – 3.20	0.07
	iauc64	0.21	0.15 – 0.29	0.48	0.22	0.18 – 0.26	0.29
	slope	1.56	1.31 – 2.60	0.41	2.46	2.13 – 2.82	0.27

LRRM = linear reference region model

NRRM = nonlinear reference region model with set initial guess

NRRM* = nonlinear reference region model with initial guess from LRRM estimates

LTM = linear tofts model

NTM = nonlinear tofts model with set initial guess

NTM* = nonlinear tofts model with initial guess from LTM estimates

MER = mean enhancement ratio, TTP = time to peak, iauc64 = initial area under the curve

IQR: inter-quartile range

wSCV: within subject coefficient of variation. Bounds: 95% lower and upper confidence intervals