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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Curr Probl Pediatr Adolesc Health Care. 2018 Jan 19;48(2):50–62. doi: 10.1016/j.cppeds.2017.12.001

FIGURE 1. Factors that may contribute to activation-related adverse events in pediatric patients.

FIGURE 1

In this functional causal diagram, white circles represent clinical and demographic risk factors as well as attributes of the medication or its interactions. Gray circles reflect intrinsic metabolism and pharmacologic factors.