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A schematic of key processes of uric acid disposition. Uric acid enters the systemic circulation by metabolic production (production rate k P). It is eliminated from the circulation by intestinal clearance and renal clearance. Renal clearance occurs by filtration in the glomeruli and as reflected by the glomerular filtration rate and partial reabsorption in the proximal tubule. The effect of reabsorption is described by the fractional excretion coefficient of uric acid (F E).
