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. 2018 Feb 27;6(5):e13614. doi: 10.14814/phy2.13614

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© 2018 Astra Zeneca. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Dependence on glomerular filtration rate of predose steady state concentration of UA in serum (third row from the top) and amount of UA in urine excreted over 24 h (bottom row). Baseline production rate of UA is shown in the top row, baseline fractional excretion coefficient of UA – in the second row from the top. Left column: Study 104 (23 values). Right column: Study 120 (16 values). Symbols: values for individual subjects. Solid lines in the top two rows: interpolation of individual values using nonlinear regression. Solid lines in the bottom two rows: model predictions using interpolated mean production rate and baseline fractional excretion coefficient. UA, uric acid.