GFR |
Glomerular filtration rate (mL/min) |
[P]50,PIN
|
Plasma concentration of an inhibitor of uric acid production resulting in half‐maximal fractional decrease in the production rate of uric acid (ng/mL) |
R
max
|
Maximum fractional decrease in the production rate of uric acid due to the inhibitor of uric acid production |
[P]50,RIN
|
Plasma concentration of an inhibitor of uric acid reabsorption resulting in half‐maximal increase in the fractional excretion coefficient (ng/mL) |
F
max
|
Maximum increase in fractional excretion coefficient due to the inhibitor of uric acid reabsorption |
CL
I
|
Intestinal clearance of uric acid (L/h) |
V
UA
|
Volume of distribution of uric acid (L) |
F
E
|
Fractional excretion coefficient of uric acid in urine |
F
E,0
|
Fractional excretion coefficient of uric acid in urine without drug treatment |
S
UA
|
Amount of uric acid in serum (mg) |
[S
UA] |
Concentration of uric acid in serum (mg/dL) |
k
P
|
Production rate of uric acid (mg/h) |
k
P,0
|
Production rate of uric acid without drug treatment (mg/h) |
X
UA
|
Excretion rate of uric acid in urine (mg/h) |
CL
UA
|
Total clearance of uric acid (L/h) |
U
UA
|
Amount of uric acid excreted in urine (mg) |
[P]PIN
|
Plasma concentration of the inhibitor of uric acid production rate |
[P]RIN
|
Plasma concentration of the inhibitor of uric acid reabsorption |