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. 2018 Feb 27;6(5):e13614. doi: 10.14814/phy2.13614
GFR Glomerular filtration rate (mL/min)
[P]50,PIN Plasma concentration of an inhibitor of uric acid production resulting in half‐maximal fractional decrease in the production rate of uric acid (ng/mL)
R max Maximum fractional decrease in the production rate of uric acid due to the inhibitor of uric acid production
[P]50,RIN Plasma concentration of an inhibitor of uric acid reabsorption resulting in half‐maximal increase in the fractional excretion coefficient (ng/mL)
F max Maximum increase in fractional excretion coefficient due to the inhibitor of uric acid reabsorption
CL I Intestinal clearance of uric acid (L/h)
V UA Volume of distribution of uric acid (L)
F E Fractional excretion coefficient of uric acid in urine
F E,0 Fractional excretion coefficient of uric acid in urine without drug treatment
S UA Amount of uric acid in serum (mg)
[S UA] Concentration of uric acid in serum (mg/dL)
k P Production rate of uric acid (mg/h)
k P,0 Production rate of uric acid without drug treatment (mg/h)
X UA Excretion rate of uric acid in urine (mg/h)
CL UA Total clearance of uric acid (L/h)
U UA Amount of uric acid excreted in urine (mg)
[P]PIN Plasma concentration of the inhibitor of uric acid production rate
[P]RIN Plasma concentration of the inhibitor of uric acid reabsorption